BackgroundThis study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa.MethodsDecision-analytic models were constructed using best available evidence sourced from unbundled data an ongoing pilot trial assessing effectiveness FiO2, pu...

Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and was verified by ELISA in another group. Information regarding acute exacerbation (AE) was collected in a one-year follow-up programme. FETUB concentrations (1652 ± 427 ng/ml) were greater in COPD patients than in controls (1237 ± 77 ng/ml). The conce...

BACKGROUND Despite catheter ablation (CA) has become an accepted treatment option for symptomatic, drug-resistant atrial fibrillation (AF), safety of this procedure continues to be cause for concern. OBJECTIVE Aim of the present multicenter study was to assess the influence of age and gender on incidence and severity of early CA complications. METHODS From January 1, 2011 to December 31, 20...

Several mycoplasma species are known to glide in the direction of the membrane protrusion (head-like structure), but the mechanism underlying this movement is entirely unknown. To identify proteins involved in the gliding mechanism, protein fractions of Mycoplasma mobile were analyzed for 10 gliding mutants isolated previously. One large protein (Gli349) was observed to be missing in a mutant m...

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Physical exercise can cause marked alterations in the structure and function of human skeletal muscle. However, little is known about the specific signaling molecules and pathways that enable exercise to modulate cellular processes in skeletal muscle. The mitogen-activated protein kinase (MAPK) cascade is a major signaling system by which cells transduce extracellular signals into intracellular...

The Nicobarese were the largest tribal group inhabiting 12 islands with major concentration in Car Nicobar. As there is no reliable information on the biophysical set up, socioeconomic and farming system characteristics of these Islands, the study aims to derive baseline information on the above aspects, which is essential for any planning process. The agricultural production in Nicobar Islands...

Matrix Gla protein (MGP) is synthesized in a vitamin K–dependent way in smooth muscle cells of the healthy vessel wall, and its mRNA transcription is substantially upregulated in atherosclerotic lesions. Here we report the preparation of a monoclonal antibody against human MGP and its use in an enzyme-linked immunosorbent assay. The intra-assay and interassay coefficients of variation in serum ...