Voltage-gated Ca(2+) channels (Ca(V)) are ubiquitously expressed in various cell types and play vital roles in regulation of cellular functions including proliferation. However, the molecular identities and function of Ca(V) remained unexplored in preadipocytes. Therefore, whole cell voltage-clamp technique, conventional/quantitative real-time RT-PCR, Western blot, small interfering RNA (siRNA)...

conclusions maternal physical activity affects children’s physical activity, and is affected by mother’s self-efficacy. yet based on the findings of this study, regarding the role model effects of mothers in children aged 10-12 years, researchers proposed that interventions related to physical activity in children would work better if they are set to increase self-efficacy in mothers, which in ...

T-type Ca(2+) currents have been proposed to be involved in the genesis of spike-and-wave discharges, a sign of absence seizures, but direct evidence in vivo to support this hypothesis has been lacking. To address this question, we generated a null mutation of the alpha(1G) subunit of T-type Ca(2+) channels. The thalamocortical relay neurons of the alpha(1G)-deficient mice lacked the burst mode...

The study aim to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation on albendazole and ivermectin in tablet dosage forms. Pure drug sample of albendazole and ivermectin were dissolved in a mixture of methanol and 1 N HCl (70:30). Two wavelengths selected for formation and solving the simultaneous equations were 248.8 nm for albendazole and 314.4 nm f...

Monopiles used as foundations for offshore wind turbines can be installed using different methods including jacking, vibratory driving and impact driving. Significant research efforts have been dedicated to the characterisation of monopile−soil interaction under lateral loading, mainly p–y curves. There has also extensive in quantifying effect installation on axial response numerical modelling ...

BACKGROUND Germline mutations of the CHEK2 gene have been reported to be associated with breast cancer. In this study, we analyzed the association of CHEK2 mutations with the risk of development of breast cancer in women of North-Central Poland. METHODS 420 women with breast cancer and 435 controls were tested for three protein truncating (IVS2 + 1G > A, 1100delC, del5395) and one missense (I...