BACKGROUND Surgical site infection is a devastating postoperative complication, and the occurrence ranges from 1% to 2% after total knee arthroplasty (TKA). The efficacy of the preoperative use of chlorhexidine for reducing infection has been debated. This meta-analysis aimed to examine the efficacy of the use of chlorhexidine to prevent surgical site infections after TKA. METHODS In February...

Antiseptic agents are increasingly used for hand hygiene and skin decolonization as key tools for the prevention of healthcare-associated infections. Chlorhexidine, a divalent, cationic biguanide, has a broad spectrum of activity and is one of the most frequently used topical antiseptic agents. Notably, there are an increasing number of prevalence studies that report reduced levels of susceptib...

BACKGROUND Chlorhexidine showering is frequently recommended as an important preoperative measure to prevent surgical site infection (SSI). However, the efficacy of this approach is uncertain. METHODS A search of electronic databases was undertaken to identify prospective controlled trials evaluating whole-body preoperative bathing with chlorhexidine versus placebo or no bath for prevention o...

Chronic rinsing with chlorhexidine, an oral-antiseptic, has been shown to decrease the saltiness of NaCl and the bitterness of quinine. The effect of acute chlorhexidine on taste has not been investigated. The purpose of the present study was to examine the effect of acute chlorhexidine rinses on taste intensity and quality of 11 stimuli representing sweet, salt, sour, bitter and savory. All st...

The study was performed to monitor the susceptibility of clinical isolates of staphylococci to chlorhexidine and antibacterial drugs in vitro. Forty-eight strains of staphylococci were isolated from Tikur Anbessa Hospital patients. All isolates were susceptible to <0.01% chlorhexidine out of which 90% were inhibited at <0.001%. Tetracycline, penicillin, and chloramphenicol were the least effect...

OBJECTIVE To evaluate the effects of oral chlorhexidine hygiene with toothbrushing on the rate of ventilator-associated pneumonia in a mixed population of critically ill patients under prolonged mechanical ventilation. METHODS Prospective, randomized, and placebo-controlled pilot study. Patients who were receiving mechanical ventilation, had been admitted less than 24 hours prior, and were an...

A meta-analysis was performed on published data on the caries-inhibiting effect of chlorhexidine treatment. The results of the various studies are difficult to evaluate because of various treatment procedures, dissimilar features of participants, and different presentations of study results. A meta-analysis provides a more structured approach than the traditional review, due to systematic analy...

We conducted a systematic review of healthcare-associated outbreaks and cross-sectional surveys related to the contamination antiseptics, disinfectants, hand hygiene products in healthcare settings low- middle-income countries (PROSPERO CRD42021266271). Risk bias was assessed by selected items ORION MICRO checklists. From 1977 onwards, 13 25 were found: 20 from Asia Africa. Products most associ...

Chlorhexidine is a widely used antiseptic with a broad spectrum of antimicrobial activities. The aim of this research is to develop a chlorhexidine thermosensitive gel as a mouth antiseptic by using lutrol F127 as a gelling agent. Due to its thermosensitive properties, lutrol has a sol-gel transition ability to change from solution stage at low temperature to the viscous gel at high temperature...