Introduction: The objective of this study is to determine the major causes of early death in acute lymphoblastic leukemia (ALL).  Methods: The following databases including PubMed, EMBASE, Science Direct and Google Scholar were searched for following terms: “acute lymphoblastic leukemia”, “early mortality”, “early death “ and “death in induction phase “. Inclusion criteria were all studies abo...

Abstract We consider fragments of uniform reflection for formulas in the analytic hierarchy over theories second order arithmetic. The main result is that any arithmetic theory $T_0$ extending $\mathsf {RCA}_0$ and axiomatizable by a $\Pi ^1_{k+2}$ sentence, $n\geq k+1$ , $$\begin{align*}T_0+ \mathrm{RFN}_{\varPi^1_{n+2}}(T) \ = T_0 + \mathrm{TI}_{\varPi^1_n}(\varepsilon_0), \end{align*}$$ \mat...

background: an increasing success in induction of labor and subsequent termination of pregnancy in presence of unfavorable cervix requires cervical ripening in order to reduce complications and to diminish the rate of cesarean sections as well as the duration of labor.  however, there is no consensus on the efficiency of conventional methods for cervical ripening.   objective: to determine and ...

BACKGROUND We introduce a new, simple portable inhalational induction device (PD) that provides co-operative inhalational induction of anaesthesia using N(2)O and subsequent sevoflurane in the preanaesthetic induction area in children. METHODS Forty-five children (30 to 94 months old age, <35 kg) who were scheduled to undergo simple operations were assigned randomly to one of three regimens. ...

Background: Gemcitabine (2′, 2′-difluoro-2′- deoxycytidine, an analogue of deoxycytidine) is a relatively new drug with wide range of anti-cancer activity. In this study, radiosensitizing effects of gemcitabine was investigated on HeLa and MRC5 human originated cell lines under both chronically hypoxic and normoxic conditions using the micronucleus (MN) assay. Materials and Methods: F...

background: in recent years, adipose tissue, due to the stem cells contained within, has found a new special place in laboratory and clinical applications. these adipose‑derived stem cells (adscs) have the same characteristics of bone marrow mesenchymal stem cells (bmscs). although bone marrow (bm) is not easily accessible and its procurements may be painful, most patients possess excess fat wh...

Objective: n present study effect of various factors including sucrose, agar, PEG, AgNO3, activated charcoal on somatic embryo induction and its subsequent regeneration was investigated using varieties Dom siah and Nemat. Methods: 330 explant (Mature embryos) of each varieties were cultured, 33/plate (100 x 15 mm), on callus induction Murashige and Skoog (MS) medium (Murashige and Sk...

Three enzymes that cause inhibition of mRNA translation, eukaryotic initiation factor 2 protein kinase PK-i, oligoisoadenylate synthetase E, and phosphodiesterase 2'-PDi, have been recently isolated from interferon-treated cells. We show that the rise in these three enzyme activities may be used to study the response of uninfected cells to interferon. For each enzyme, a specific microassay that...

Induction of cytochromes P450 (P450s) by drugs can lead to drug-drug interactions. Primary hepatocytes have been reported to retain inducible P450s. To optimize the use of primary hepatocytes for predicting induction of P450 (CYP 3A and 2B) expression in vivo, both culture conditions and expression of induction potentials were investigated. In rat hepatocytes, basal CYP 3A1/2 expression was bet...

background: the most favorable method for cervical ripening is not fully agreed upon by practitioners; however, vaginal administration of isosorbide mononitrate (imn) is considered a low‑risk method of labor induction for pregnant women at full term. our study was designed to assess the effect of imn on cervical ripening and labor induction among primiparous women in iran. materials and methods...