Although somatically mutated autoantibodies are characteristic of many autoimmune diseases, the processes that can lead to their development remain poorly understood. We have examined the formation of autoreactive memory B cells in PevHA mice, which express the influenza virus PR8 hemagglutinin (HA) as a transgenic membrane bound neo-self-Ag. Using a virus immunization strategy, we show that PR...

Purpose: assessment of the use photosynthetically active radiation (PAR) by soybeans while using improved cultivation technology on irrigated lands in Rostov region. Materials and methods. The studies were carried out at Bessergenevskoe Agricultural Enterprise LLC 2019–2021. laying field experiments soybean crops, recording observations according to methods VNIIMK All-Union Scientific Research ...

Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet beta cells of InsHA mice leads to peripheral tolerance of HA-specific T cells. To examine the onset of tolerance, InsHA mice were immunized with influenza virus A/PR/8 at different ages, and the presence of nontolerant T cells was determined by the induction of autoimmune diabetes. The data revealed a neonat...

Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected ...

Minor histocompatibility Ags (mHags) are important targets of the graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation. mHags are HLA-restricted polymorphic peptides expressed on normal and leukemia cells. Vaccination with hematopoiesis-restricted mHag peptides, such as HA-1, may boost the graft-versus-leukemia effect. However, some animal studies indicate that pe...

BACKGROUND ATP-binding cassette transporter A1 (ABCA1) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against Hypoalphalipoproteinemia (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytoki...

The conservation technologies and traditional techniques were evaluated at Adaptive Research Farm Gujranwala Pakistan during Rabi 2007-2008 and 2008-2009. The sowing techniques evaluated were broadcasting (T-1), Rotary Tillage Drill (T-2), Zero Tillage Drill (T-3) and Rabi Drill (T-4). Rotary Tillage Drill showed significantly high germination count (220.50 m -2 ) followed by Rabi Drill (211.50...

Adsorbed natural gas has various advantages and is relatively more economical than liquefaction and compression. Carbon nanotubes can be introduced as a new candidate for natural gas storage. In this study, adsorption of methane was firstly studied on the as-prepared multi-walled carbon nanotubes, and then chemical and physical treatment of MWCNTs was performed to enhance the methane adsorp...

Optimization of long term immunity depends on the functional persistence of memory T cells; however, there are no defined strategies for promoting memory T cell function and survival. In this study, we hypothesized that varying the strength of the recall stimulus could modulate the function and survival potential of memory CD4 T cells. We tested the ability of peptide variants of influenza hema...

This article presents the results of studying yield and fruit quality 21 introduced apple varieties winter ripening in Podolsk Research Station Horticulture. According to a five-year study (2016-2020), evaluation is based on set basic characteristics: early fruiting, yield, marketability, taste viability fruits. As result research, Count Ezzo, Siabrina, Selena, Nadzeina were recognized as best....