Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

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lnrroduced In 19fi3, the balloon em bolectomy carhertr hal> proved to be ~ n im porranc contribution fO rhe deveJopmt"nt of endovascular devices to assIst in the treatmen t of peripheral vascular ocdusi~e disease (l,2). Ie has al~o provided a template for the deslgn of orher, more speuabzed c<l(hner tools to address the remova l of the residual thrombus associmed with incom plcre throm boem bol...

Composite restoration materials have been in use for more than two decades as an aesthetic alternative to metal restorations in the posterior region, which bears a great deal of the masticatory load, with increasing frequency in recent years (Kelsey et al, 2000). The early clinical data on the posterior region, gathered in the early 1980s, was not encouraging, primarily due to insufficient mech...

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GIST has been shown to over-express c-KIT (CD117), the receptor tyrosine kinase. Imatinib (STI571 or Glivec) is a new type of tyrosine kinase inhibitor that selectively inhibits various tyrosine kinases and has been successfully used to treat GIST. In this study we have...

3,4-dihydropyrimidinones and their derivatives are synthesized via biginelli routes involving an aromatic aldehydes, ethylacetoacetates and urea in one-pot procedure by using cds nanoparticles as efficient heterogeneous catalyst in solvent-free conditions. compared with classical biginelli reaction reported in 1893, this new method provides much improved modification in terms of simplicity. the...