1 prefrontal responses 2 3 Ryan D. Darling 4 Kanako Takatsuki 5 Amy L. Griffin 6 Stephen D. Berry 7 8 a. Department of Psychology and Center for Neuroscience, Miami University, Oxford, OH 9 45056 10 b. Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of 11 Tokyo, Tokyo 113-0033, Japan 12 c. Department of Psychology, University of Delaware, Newark, Delaware 19716 ...

For some physics students, the concept of a particle travelling faster than the speed of light holds endless fascination, and Čerenkov radiation is a visible consequence of a charged particle travelling through a medium at locally superluminal velocities. The Heaviside–Feynman equations for calculating the magnetic and electric fields of a moving charge have been known for many decades, but it ...

We study the asymptotics of recurrence coefficients for monic orthogonal polynomials πn(z) with the quartic exponential weight exp[−N( 1 2z2 + 14 tz)], where t ∈ C and N ∈ N, N → ∞. Our goal is to describe these asymptotic behaviors globally for t ∈ C in different regions. We also describe the “breaking” curves separating these regions, and discuss their special (critical) points. All these pie...

Aspirin is unique among clinically used nonsteroidal antiinflammatory drugs in that it irreversibly inactivates prostaglandin (PG) H2 synthase (PGHS) via acetylation of an active-site serine residue. We report the synthesis and characterization of a novel acetylating agent, O-acetylsalicylhydroxamic acid (AcSHA), which inhibits PGE2 synthesis in vivo and blocks the cyclooxygenase activity of PG...

This study aimed to investigate the circulation of Orthobunyavirus species in the state of Mato Grosso (MT) Brazil. During a dengue outbreak in 2011/2012, 529 serum samples were collected from patients with acute febrile illness with symptoms for up to five days and 387 pools of female Culex quinquefasciatus captured in 2013 were subjected to nested-reverse transcription-polymerase chain reacti...

Integrins regulate cell adhesion and motility through tyrosine kinases, but initiation of this process is poorly understood. We find here that Src associates constitutively with integrin alphaIIbbeta3 in platelets. Platelet adhesion to fibrinogen caused a rapid increase in alphaIIbbeta3-associated Src activity, and active Src localized to filopodia and cell edges. Csk, which negatively regulate...

We developed a ratiometric method capable of estimating total hemoglobin concentration from optically measured diffuse reflectance spectra. The three isosbestic wavelength ratio pairs that best correlated to total hemoglobin concentration independent of saturation and scattering were 545/390, 452/390, and 529/390 nm. These wavelength pairs were selected using forward Monte Carlo simulations whi...

We looked into the problem that the quantitative values of 123I data vary according to collimator type. First, we made the assumption that the quantitative values of 123I data are degraded by the scattered photons from the 529 keV component which contaminate the 159 keV imaging data. Then, the 123I Dual Window (IDW) method was proposed to improve the quantitative values of the 123I data. The ID...

Arthropods evolved blood-feeding lifestyles on more than 20 independent occasions. A comparison of sialomes (secretory salivary gland protein family repertoires) corroborates this and indicates that unique protein families are found for different blood-feeding lineages. Closely related lineages considered to have evolved blood-feeding behavior independently might share similar sets of protein f...

We defined the epitopes recognized by three influenza A virus-specific, H-2Kd-restricted CD8(+) cytotoxic T-lymphocyte (CTL) clones: H1-specific clone A-12, H2-specific clone F-4, and H1- and H2-cross-reactive clone B7-B7. The A-12 and B7-B7 clones recognized the same peptide, which comprises amino acids 533 to 541 (IYSTVASSL) of A/PR/8 hemagglutinin (HA). The F-4 and B7-B7 clones both recogniz...