Background Alzheimer’s disease (AD) carries an increased risk of seizures and subclinical epileptiform activity (Vossel et al. 2016). Network hyperexcitability which is the underlying phenomenon epileptic manifestations thought to contribute AD pathophysiological processes. Recently we demonstrated that greater degree neural synchronization deficits within 2-8Hz range frequency oscillations are...

Leukocyte recruitment from the bloodstream to surrounding tissues is an essential component of the immune response. Capture of blood-borne leukocytes onto vascular endothelium proceeds via a two-step mechanism, with each step mediated by a distinct receptor-ligand pair. Cells first transiently adhere, or "roll" (via interactions between selectins and sialyl-Lewis-x), and then firmly adhere to t...

isotactic poly (1-butene), ipbu-1, was synthesized by using a metallocene catalyst. the thermodynamic phase behavior of polymer–organic solvents systems is very important in every polymer application.  in this paper, the solid–liquid equilibrium of ipbu-1 with different organic solvents (1-heptyne, cyclo octane) was studied by a mathematical model. by considering the experiments temperature-mol...

The software industry has become one of the world's key industries in recent decades. The tremendous amount of growth in software development industry has taken a pace and has become a driving force. It has grabbed the attention of researchers due to its subtle impact on world's economy and society. Software engineering deals with the design and development of high quality and reliable software...

The UML activity diagram is graphical presentation that describes the operational process and related causes used in each stage of the system. For understanding and accurate communication, the UML standard is required for determining the congruent and consistent format application. To detect the misconception and incorrect notation, this paper presents an automation approach to reviewing UML ac...

Formalization of UML models now becomes a requisite action by most of the software designers. UML is semiformal in nature. So it becomes necessary to formalize the UML which would reduce the overall complexity of software design. Today as software becoming more interactive and distributed in nature, the formal syntax and automated verification analysis of behavioral aspect of any model becomes ...

Modeling in general is “an abstract representation of a specification, design or system from a particular point of view”. System modeling is ”a technique to express, visualise, analyse and transform the architecture of a system”. The Unified Modeling Language (UML) is “a language for specifying, visualising, constructing, and documenting the artefacts of a software-intensive system as well as f...

Introduction: Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in mild to severe conditions. The present study was conducted to investigate the effects of memantine on the spontaneous firing frequency of CA1 pyramidal neurons in rats caused by an electrical lesion of Nucleus Basalis Magnocellularis (...

there are many reasons for decrease of the functional activity of the brain like aging of the neurons, bacterial diseases and neuro inflammations. nowadays, the effects of exercise on physical and mental health have been proven but its effects on motor functions as well as neuro inflammation is an issue that has recently been studding. neuro inflammation is a mechanism that can be caused by bac...