Objectives Studies have indicated advantageous properties of [DOTA-DPhe1, Tyr3] octreotide (DOTATOC) in tumor models and labeling with gallium. Breast cancer is the second leading cause of cancer mortality in women, and most of these cancers are often an adenocarcinoma. Due to the importance of target to non-target ratios in the efficacy of diagnosis, the pharmacokinetic of 68Ga-DOTATOC in an a...

OBJECTIVE To investigate the effects of mTOR inhibition on drug resistance in lung adenocarcinoma after combined radiation and erlotinib therapy. RESULTS Combined radiation and erlotinib therapy produced clear radiosensitization effects both in vitro and in vivo; however, tumor cells remained drug resistant. Additionally, combined radiation and erlotinib therapy significantly increased p-AKT ...

Cancers detected at a late stage are often refractory to treatments and ultimately lethal. Early detection can significantly increase survival probability, but attempts to reduce mortality by early detection have frequently increased overdiagnosis of indolent conditions that do not progress over a lifetime. Study designs that incorporate biomarker trajectories in time and space are needed to di...

BACKGROUND Indoleamine 2,3-dioxygenase (IDO), an enzyme for tryptophan metabolism through the kynurenine pathway, exhibits an immunosuppressive effect and induces immune tolerance in tumor cells. The effects of IDO on pancreatic cancer are poorly understood. This study aimed to investigate the expression and prognostic significance of IDO in pancreatic cancer. METHODS We evaluated the protein...

Aim: The current study’s aim is to correlate clinical variables with histopathological findings of pre-malignant and malignant lesions the intestinal tract. Methods: sample size includes all endoscopic biopsies surgically resected specimens tract received at Department Pathology, S.V. Medical College, Tirupathi for 2 years from November 2016 October 2018. All are fixed in 10% formalin stained H...

Although adenocarcinoma is rapidly becoming the most common form of lung cancer in the United States, the difficulty in obtaining lung cancer families and representative samples of the various stages of adenocarcinoma progression has led to intense study of mouse models. As a powerful approach to delineating molecular changes, we have analyzed 15 early-passage mouse cell lines by spectral karyo...

PURPOSE Green tea consumption has been shown to exhibit cancer-preventive activities in preclinical studies. Polyphenon E (Poly E) is a well-defined green tea-derived catechin mixture. This study was designed to determine the effects of Poly E on the growth of human Barrett's and aerodigestive adenocarcinoma cells and the mechanisms involved in growth regulation by this agent. EXPERIMENTAL DE...

background and aim: salivary gland tumors classification continuously undergoes alternations, especially in the recent years. this study used immunohistochemical markers for distinguishing between polymorphous low-grade adenocarcinoma (plga) and adenocarcinoma carcinoma (adcc) which have several overlapping histological and clinical features. materials & methods: ten adcc and eight plga with fi...

colloid carcinoma, also called mucinous carcinoma, is classified as a histologic variant of adenocarcinoma. because the colloid carcinoma of the biliary tree is exceedingly rare, the imaging characteristics and the clinical features of colloid carcinoma remain relatively unknown. we report a case of colloid carcinoma of the common bile duct and its accompanied metastatic lymphadenopathies with ...