Mục tiêu: Đánh giá vai trò của nồng độ Osteocalcin (OC), Beta-CrossLaps (β-CTX) huyết thanh trong theo dõi đáp ứng điều trị với Alendronate ở phụ nữ cao tuổi loãng xương. Đối tượng và phương pháp nghiên cứu: Nghiên cứu dọc được thực hiện trên 58 (≥ 60 tuổi) xương tại phòng khám Nội cơ khớp Lão khoa, Bệnh viện Đại học Y Dược TP. Hồ Chí Minh từ tháng 10 năm 2021 đến 2022. nhân ghi nhận thông tin ...

Adverse effects associated with the use of bisphosphonates are infrequent and consist of pyrexia, renal function impairment, and hypocalcemia. Bisphosphonates-associated osteonecrosis of the jaws is an uncommon but potentially serious complication of intravenous bisphosphonate therapy in cancer patients. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alend...

Phosphonates have emerged as an alternative for functionalization of titanium surfaces by the formation of homogeneous self-assembled monolayers (SAMs) via Ti-O-P linkages. This study presents results from an investigation of the modification of Ti6Al4V alloy by chemisorption of osseoinductive alendronate using a simple, effective and clean methodology. The modified surfaces showed a tailored t...

Charcot neuroarthropathy is defined by painful or relatively painless bone and joint deformity in limbs that have lost sensory innervation (1). The incidence is 0.1–5% in diabetic patients with peripheral neuropathy (2,3). The pathogenesis of Charcot neuroarthropathy is unknown (1,4). In acute Charcot neuroarthropathy, osteoclast activity increases (5). Alendronate is a bisphosphonate that indu...

Alendronate sodium, a bisphosphonate drug, is used to treat osteoporosis and other bone diseases. The present study was designed to conduct comparative bioavailability analysis of oral formulations of alendronate sodium through an open-label, randomized, 2-sequence, 2-period crossover study. Healthy adult male Pakistani volunteers received a single 70mg dose of the test or reference formulation...

Introduction: Alendronate, a second generation bisphosphonate, is known to increase bone density by inhibiting osteoclastic bone resorption. It is clincally used to treat osteoporosis, Paget’s disease and hypercalcemia associated with malignancy [1]. In clinical trials and animal studies, the effects are typically quantified by measuring bone mineral density. In this study, we sought to determi...

The long-term success of arthroplastic joints is dependent on the stabilization of the implant within the skeletal site. Movement of the arthroplastic implant within the bone can stimulate osteolysis, and therefore methods which promote rigid fixation or bone growth are expected to enhance implant stability and the long-term success of joint arthroplasty. In the present study, we used a simple ...

Findings from endoscopic studies in patients with esophagitis caused by alendronate are associated with chemical esophagitis, similar to that caused by acetylsalicylic acid.7 The pathophysiological mechanism involved in these cases was direct irritation of the mucosa due to prolonged exposure to the drug. The same mechanism could apply to our patients who allowed tablets to dissolve in their mo...