We report the first full synthesis of novel spiroether derivatives via reaction 4-oxobut-2-enoates and alloxan. Our features single-step assembly, mild conditions, good yi...

the effects of chronic metabolic acidosis, alkalosis and alloxan-induced ketoacidosis on g6pd activity of rat kidney, liver and erythrocytes were studied. metabolic acidosis significantly increased the activity of kidney enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme activities. alkalosis did not make a significant change in the kidney or liver enzyme activity but sligh...

In order to clarify the peculiarities of osmotic concentration urine in dynamics development alloxan-induced experimental diabetes mellitus (DDM), studies were conducted on 54 sexually mature non-linear male white rats, which DDM was simulated by a single intraperitoneal injection alloxan solution (Alloxan monohydrate, "Acros Organics", Belgium) at dose 160 mg/kg body weight after previous 12-h...

Increased activities of maltase and sucrase of small intestinal mucosa were found in alloxandiabetic mice. Adrenalectomy did not affect the activities of the enzymes in normal mice, but lowered those of alloxan-diabetic mice as well as blood sugar level. Administration of glucocorticoid raised the enzyme activities in normal mice, non-diabetic adrenalectomized mice and adrenalectomized al1oxan-...

stomach tube to alloxan-diabetic rats and the urine of these animals collected for the next 24 hours. The rats had access to food. The urinary glucose was isolated as the osazone, which was then converted to the osotriazole derivative. The results obtained with four rats are recorded in the table. The purity of the osazones and osotriazoles was established by the determination of nitrogen cont....

Amrithadi Churnam - a compound ayurvedic preparation made up of Tinospora cordifolia, Salacia prenoides, Curcuma longa, Tribulus terrestris and Emblica Officinalis was screened for its antidiabetic activity. From the studies it could be established that Amrithadi churnam at a dose level of 100mg/kg b.w. was the optimum dose in alloxan diabetic rats. No toxic effects were observed as evidenced b...