Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid- CETP peptide (TT-CETP) was mixe...

an adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for used. the basic action of adjuvants is stimulating adaptive immune responses. adjuvants, recently licensed for human utlization, involve alum squalane oil or water emulsion, influenza viro...

BACKGROUND Visceral leishmaniasis (VL) is a severe vector-born disease of humans and dogs caused by Leishmania donovani complex parasites. Approximately 0.2 to 0.4 million new human VL cases occur annually worldwide. In the new world, these alarming numbers are primarily due to the impracticality of current control methods based on vector reduction and dog euthanasia. Thus, a prophylactic vacci...

Treatment of tar-containing wastewater is necessary for the successful operation of biomass gasification plants (BGPs). In the present study, tar-containing wastewater was treated using lime and alum for the removal of in-organics, followed by adsorption on powdered activated carbon (PAC) for the removal of organics. Limealum experiments were performed in a jar apparatus and activated carbon st...

INTRODUCTION The most widely used protocol for the induction of experimental allergic airway inflammation in mice involves sensitization by intraperitoneal (i.p.) injections of the antigen ovalbumin (OVA) used in conjunction with the adjuvant aluminium hydroxide (alum). Although adjuvants are frequently used, there are questions regarding the necessity of alum for murine asthma studies due to t...

Background: well water provide that comes from a layer of soil is relatively close to the ground surface, therefore it easily exposed contamination through seepage. In general, seepage human excreta, latrines or and animals, as waste itself, either because floor sewerage are not impermeable water. The condition construction way drawn can also be source contamination, for example wells with open...

The use of biodegradable polymer matrices as a single-dose vaccine delivery system was investigated using tetanus toxoid (TT) and diphtheria toxoid (DT). BALB/c mice were immunized with TT or DT in different formulations including individual, in minipellet and aluminum hydroxide (alum), and the antibody responses were monitored for 48 weeks. Antigens entrapped in minipellet elicited higher anti...

The adjuvant potential of two mesoporous silica nanoparticles (MSNs), SBa-15 and SBa-16, was assessed in combination with a recombinant HSP70 surface polypeptide domain from Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia (PEP). The recombinant antigen (HSP70212-600), previously shown as immunogenic in formulation with classic adjuvants, was used to immunize BALB/c...

BACKGROUND Silica particles cationized by dioctadecyldimethylammonium bromide (DODAB) bilayer were previously described. This work shows the efficiency of these particulates for antigen adsorption and presentation to the immune system and proves the concept that silica-based cationic bilayers exhibit better performance than alum regarding colloid stability and cellular immune responses for vacc...