BACKGROUND Limb girdle muscular dystrophy type 2G (LGMD2G) is a subtype of autosomal recessive muscular dystrophy caused by mutations in the telethonin gene. There are few LGMD2G patients worldwide reported, and this is the first description associated with early tibialis anterior sparing on muscle image and myopathic-neurogenic motor unit potentials. CASE PRESENTATION Here we report a 31 yea...

Observing the actions of others has been shown to modulate cortico-spinal excitability and affect behaviour. However, the sensorimotor consequences of observing errors are not well understood. Here, participants watched actors lift identically weighted large and small cubes which typically elicit expectation-based fingertip force errors. One group of participants observed the standard overestim...

Electromyography (EMG) is a technique that gives information about the neuromuscular pattern and function which commonly-used in practice of neurology. With this method, signals obtained from muscle cells using an amplificatore are enhanced to amount enough study on. The potentials monitored called Motor Unit Action Potentials (MUAPs). In study, findings gathered by simulation dipole model for ...

The significant decline in motor neuron number after approximately 60 yr of age is accompanied by a remodeling of the neuromuscular system so that average motor unit force increases and the ability of old adults to produce an intended force declines. One possible explanation for the loss of movement precision is that the remodeling increases the difference in recruitment forces between successi...

Abstract Introduction Motor neuron loss is the primary pathologic feature of amyotrophic lateral sclerosis (ALS). An estimate number surviving motor units (MUs) represents a direct measure disease state in ALS. The objective study to compare MU estimation (MUNE) using multipoint stimulation method (MPS) and compound muscle action potentials (CMAP) amplitude patients with Methods Twenty-eight AL...

A technique is described for the electrophysiological investigation of motor-point muscle biopsies and the data from 13 biopsies are reported. It was not possible to demonstrate any influence of disease upon the resting potentials of individual biopsies, but resting potentials were in general lower than those reported for limb muscle in vivo. Miniature end-plate potentials (MEPPs) in clinically...

Muscle fibers of the genioglossus (GG) form the bulk of the muscle mass at the base of the tongue. The motor control of the tongue is critical for vocalization, feeding, and breathing. Our goal was to assess the patterns of motor innervation of GG single motor units (SMUs) in humans. Simultaneous monopolar recordings were obtained from four sites in the base of the tongue bilaterally at two ant...

Objectives: To study the correlation between anatomical parameters and EMG signals by means of simulations. Methods: A mathematical model of the electrical activity from muscle ®bres and motor units has been developed. The electrical ®elds around the muscle ®bres are simulated using a line source model. The model permits the simulation of single muscle ®bre action potentials obtained by SFEMG, ...