The majority of the antioxidant and antidiabetic activities of fruits are anthocyanins; a group of polyphenolics that are responsible for the color of many fruits, vegetables and flowers. The harvesting time, storage conditions, maturity, extraction steps etc. are very important for the biological activities based on the alteration of chemical composition. The free radical scavenging and antidi...

In the current investigation, 474 endophytic fungi were isolated from 1200 plant parts of four species Indian traditional medicinal Salacia collected in different seasons. Among them, Fusarium oxysporum, Penicillium notatum, Pestalotiopsis sps and Phoma as a dominant genus S. chinensis, oblonga, fruticosa macrosperma respectively. Most isolates have shown potential anti-diabetic activity throug...

introduction: α-amylase is a major form of amylase found in humans and other mammals. it is the special key enzyme involved in carbohydrates breakdown. inhibition of this enzyme could be used in treatment of diabetes. in this study, the effect of ten iranian macrolichens on alpha amylase were tested. methods: different concentrations of the extracts (25, 50 and 75 mg/ml) were incubated with enz...

An efficient and rapid affinity-based screening method for directly fishing out natural alpha-glucosidase inhibitors from Cyperus. rotundus extract by using immobilized enzyme technology combined with UHPLC-QTOF MS analysis was established. As a results, without time-consuming and laborious isolation workload and false positive interference, five natural alpha-glucosidase inhibitors were succes...

Medicinal plants have been conventionally used to sustain health and treat many diseases such as diabetes for years. Spinacia oleracea L., common name palak, belong the class Amaranths family Amaranthaceous. It is an anti-bacterial, antidiabetic, anticancer, anti-inflammatory, antioxidant, hepatoprotective agent. In this study, methanol, ethanol, n-hexane aqueous extracts of leaf were evaluate ...

Due to its variety of biological activities, rhubarb has been widely applied worldwide with a long history. However, the potential bioactive compounds in Rheum tanguticum responsible for hypoglycemic, hypolipidemic, and anti-hyperuricemic activities as well their underlying mechanisms remain elusive. In order explore these specific multifunctional ingredients, vitro α-glucosidase pancreatic lip...

Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, nitric oxide (NO) scavenging reducing power by ferric activity plasma (FRAP) method. Additionally, anti-diab...

BACKGROUND N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase of glycogen-debranching enzyme in the liver, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Because the reduction of the glycogenolytic rate may be one of the mechanisms of myocardial p...