Antiphospholipid antibodies are important in the etiology of recurrent pregnancy loss. To date, most studies have concentrated on antibodies to cardiolipin specifically. In this study, the serum of 352 women with recurrent pregnancy loss was studied by enzyme-linked immunosorbent assay for antibodies to six phospholipid epitopes: cardiolipin, phosphoserine, phosphoglycerol, phosphoethanolamine,...

Primary antiphospholipid syndrome (APS) is a thrombophilic disorder not associated with connective tissue diseases or with autoimmune diseases. We report a 39-year-old female with a mechanical prosthetic mitral valve and a primary antiphospholipid syndrome. Anticoagulation with warfarin was changed for tinzaparine. Four days after the change, the patients was admitted in cardiogenic shock. A tr...

A 23-year-old woman with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome presented with 1-month history of persistent low back pain radiating to the left flank. She had been maintained on lowdose corticosteroid and anticoagulant for more than 3 years. Plain radiography of the lumbar spine revealed no abnormality. However, L-spine magnetic resonance images (MRIs) sh...

We report a case of a patient with Systemic Lupus Erythematosus (SLE) complicated by the antiphospholipid syndrome and recurrent episodes of transverse myelitis. Transverse myelitis is a rare complication of SLE and most cases are associated with the presence of an antiphospholipid antibody (APA). The pathogenic mechanism oftransverse myelitis in this condition may result from a vasculitic proc...

Antiphospholipid antibody syndrome is characterized by venous and/or arterial thrombosis and/or pregnancy morbidity associated with antiphospholipid antibodies (aPL), such as anticardiolipin antibodies, anti beta 2 glycoprotein I antibodies and positive lupus anticoagulant test. This syndrome may potentially affects any organ system including the skin. Livedo reticularis is the most frequently ...

OBJECTIVE Antiphospholipid antibody (aPL) specificity for aPL-related events was evaluated in systemic lupus erythematosus (SLE). METHODS A study was carried out on 105 patients affected with SLE comparing the prevalence of lupus anticoagulant (LA) and IgG and IgM anticardiolipin antibodies (aCL) between patients with and without features of antiphospholipid syndrome (APS). Antiphospholipid a...

Spontaneous coronary artery dissection (SCAD) is an extremely uncommon cause of myocardial infarction, occurring predominantly in women during or after pregnancy. The exact aetiology is unknown. This report describes a 33 year postpartum woman with diagnosed SCAD who tested positive for anticardiolipin antibody. This is the first case of SCAD in a patient with antiphospholipid antibody. The aut...

Antiphospholipid antibodies (aPL) represent a heterogeneous group of antibodies that recognize various antigenic targets including beta2 glycoprotein I (beta2GPI), prothrombin (PT), activated protein C, tissue plasminogen activator, plasmin and annexin A2. The most commonly used tests to detect aPL are: lupus anticoagulant (LAC), a functional coagulation assay, anticardiolipin antibody (aCL) an...