In this study, we have examined the potential of second-generation antisense chimeric 2'-O-(2-methoxy)ethyl/DNA phosphorothioate oligonucleotides (ONs) to affect cell growth through non-antisense mechanisms. Evaluation of a series of ONs demonstrated that only a small number were cytotoxic at concentrations close to those required for antisense activity. Toxicity of the ONs appeared to be seque...

The ONS is a central lookup service used in the EPCglobal network for retrieving the location of information about a specific EPC. This centralized solution lacks scalability and fault tolerance. We present the design principles of a distributed solution for ONS lookup service. In distributed systems, the problem of providing a scalable location service requires a dynamic mechanism to associate...

Antisense oligonucleotides (ONs) have great therapeutic potential for conditions in which aberrant protein production results in pathology. This method of reducing the expression of a target gene is both precise and sequence-specific. Although there are many applications for antisense ONs as central nervous system (CNS) therapeutics, systemically administered antisense ONs must be capable of cr...

NGC 2915 is a blue compact dwarf galaxy with a very extended H I disk. This disk shows a short central bar and extended spiral arms, both reaching far beyond the optical component. We use Tremaine & Weinberg's (1984) method to measure the pattern speed of the bar and spiral arms from H I radio synthesis data. Our measurements yield a pattern speed of Ω p = 0.21 ± 0.06 km s −1 arcsec −1 (8.0 ± 2...

Denote by LZ(w) the coded form of a string w produced by Lempel-Ziv encoding algorithm. We consider several classical algo-rithmic problems for texts in the compressed setting. The rst of them is the equality-testing: given LZ(w) and integers i; j; k test the equality: wi: : : i + k] = wj : : : j + k]. We give a simple and eecient randomized algorithm for this problem using the nger-printing id...

Many defects causing bridges, breaks, and transistor stuck-ons in static CMOS circuits are not detected by tests generated using the traditional single stuck-at fault model. These undetected, non-traditional faults may be detected as increased propagation time or as excessive quiescent power supply current (I DDQ). In this paper we compare the cost of testing for excess I DDQ caused by bridge, ...

I briefly review the properties of the gas flow in and around the region of the bar in a disc galaxy and discuss the corresponding inflow and the loci of star formation. I then review the flow of gas in barred galaxies which have an additional secondary bar. Finally I discuss the signatures of bars in edge-on galaxies.

Results and methodology on the effectiveness of entertainment click-ons in edutainment software are reported in this paper. They used a modified version of "Counting on Frank" software, which made a recording in a log file at each mouse-click, keypress, or screen change. The log files provided detailed information for them to calculate statistics of the time spent on click-ons, the findability ...

A health economic analysis was performed to assess the economic impact on the national health care budget of using oral nutritional supplements (ONS), being a food for special medical purposes also known as medical nutrition, for the treatment of disease related malnutrition (DRM) in the community in the Netherlands. An economic model was developed to calculate the budget impact of using ONS in...