Twenty mucin genes have been identified and classified in two groups (encoding secreted membrane-bound proteins). Secreted mucins participate mucus formation by assembling a 3-dimensional network via oligomerization, whereas are anchored to the outer membrane mediating extracellular interactions cell signaling. Both associated with carcinogenesis progression epithelial cancers, therefore consid...

HEALTH ISSUE: In Canada, cancers of the endometrium, ovaries, vulva, vagina, placenta and adnexa account for 11% of all malignant neoplasms in women and 81% of all genital cancers. Although the incidence and mortality from vulvar and vaginal cancers are very low, endometrium and ovarian cancer are important public health problems. KEY FINDINGS: In Canada, there has been no appreciable improveme...

We demonstrate that tumor-bearing hosts permit the outgrowth of "potentially malignant" cells that are located at a different site. These second cancers continued to grow and kill their hosts even though they retain the "premalignant" phenotype, even after removal of the original malignancy. The potentially malignant cells used in these experiments were ultraviolet light- or methylcholanthrene-...

Immune checkpoint inhibitors have revolutionized the management of mismatch repair-deficient (MMR-D)/microsatellite instability-high (MSI-H) gastrointestinal cancers, particularly colorectal cancer. Cancers with MMR-D/MSI-H genotype often carry a higher tumor mutation burden frameshift alterations, leading to increased mutation-associated neoantigen (MANA) generation. The dramatic response seen...

background: the two most frequently diagnosed cancers among women worldwide are breast and cervical cancers. the objective of the present study was to classify the different countries based on the death rates from sex specific cancers. methods : in this cross-sectional study, we used dataset regarding death rate from breast, cervical, uterine, and ovarian cancers in 190 countries worldwide repo...

Guideline-based cancer screening does not reduce all-cause mortality in part because persons presenting for face much higher risks of dying other cancers. With new technologies that can simultaneously screen multiple deadly cancers, reductions both cancer-specific and may be within long-term reach.

Background & Aim: Female genital cancers are the third most common type of malignancy among women. Considering the importance of these cancers, the present study was conducted to determine the age-standardized rate (ASR) of female genital cancers in Iran. Methods & Materials: In this systematic review, six international databases (Medline/PubMed, ProQuest, Scopus, Embase, ScienceDirect, and Go...

Background and aim: Head and neck cancers are the tenth most common cancers worldwide. Since these cancers can cause severe complications and mortality, early diagnosis and investigation of their prevalence in various regions may be life-saving. Therefore, this study evaluated the prevalence of head and neck cancer over a 10-year period in Gilan province, Iran. Materials and methods: This is a...