Zinc chlorochromate nonahydrate is easily prepared from the aqueous solution of chromium trioxide and zinc chloride in quantitative yield. This oxidant, in methylene chloride and at room temperature, oxidizes thiols to their disulfides. Acetals and thioacetals are deprotected to their corresponding carbonyl compounds. Sulfides are selectively converted to ther sulfoxides or sulfones. Arylox...

A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity. Replacement of indolyl moiety with 2-alkylthio-1-benzyl-5-imidazolyl substituent afforded 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino...

In the present study, the interactions of three different lithium species Li+, Li3+ and CH3Li with several different sites of the most stable tautomers of DNA nucleo-bases are presented. This investigation is based on the results of thermochemical properties, Quantum Theory of Atoms in Molecules (QTAIM) and Natural Bond Orbi...

The folding of proteins is directed by a variety of interactions, including hydrogen bonding, electrostatics, van der Waals’ interactions, and the hydrophobic effect. We have argued previously that an n!p* interaction between carbonyl groups be added to this list. In an n!p* interaction, the lone pair (n) of one carbonyl oxygen overlaps with the p* antibonding orbital of another carbonyl group....

Asparagine and aspartate are known to adopt conformations in the left-handed alpha-helical region and other partially allowed regions of the Ramachandran plot more readily than any other non-glycyl amino acids. The reason for this preference has not been established. An examination of the local environments of asparagine and aspartic acid in protein structures with a resolution better than 1.5 ...

The five major components of the monomeric haemoglobin from Glycera dibranchiata were separated and characterized by absorption spectroscopy, isoelectric focusing, azide-binding affinities and nitrosyl autoreduction kinetics. The differences found among the components are discussed in terms of haem-pocket variations. In addition, the Fourier-transform i.r. spectra of pooled monomeric haemoglobi...

Carbonyl compounds are ubiquitous in the atmosphere and either emitted primarily from anthropogenic and biogenic sources or they are produced secondarily from the oxidation of volatile organic compounds. Despite a number of studies about the quantification of carbonyl compounds a comprehensive description of optimised methods is scarce for the quantification of atmospherically relevant carbonyl...

This article reports a study of the thermo-oxidation and biodegradation in the soil of low-density polyethylene/starch films (LDPE/starch) by infrared spectroscopy: Films of LDPE/Starch blends of different composition (starch content range from 0 to 15% w/w),were prepared and exposed to thermo-oxidation at different temperatures at 80, 90 and 100°C,and buried in the soil of public dump duri...

This study was conducted to evaluate the cytoprotection of various extracts and bioactive compounds found in Pistacia vera againts cytotoxicity, ROS formation, lipid peroxidation, protein carbonylation , mitochondrial and lysosomal membrane damages in cell toxicity models of diabetes related carbonyl (glyoxal) and oxidative stress (hydroperoxide). Methanol, water and ethyl acetate were used to ...

This study was conducted to evaluate the cytoprotection of various extracts and bioactive compounds found in Pistacia vera againts cytotoxicity, ROS formation, lipid peroxidation, protein carbonylation , mitochondrial and lysosomal membrane damages in cell toxicity models of diabetes related carbonyl (glyoxal) and oxidative stress (hydroperoxide). Methanol, water and ethyl acetate were used to ...