نتایج جستجو برای: cd8 cd28 regulatory t cells

تعداد نتایج: 2030475  

2017
Jeffrey Dock Christina M Ramirez Lance Hultin Mary Ann Hausner Patricia Hultin Julie Elliott Otto O Yang Peter A Anton Beth D Jamieson Rita B Effros

A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8+ T cells with features of replicative senescence, such as inability to proliferate, absence of CD28 expression, shortened telomeres, loss of telomerase activity, enhanced activation, and increased secretion of inflammatory cytokines. Importantly, oligoclonal expansions of these cells are associated with i...

Journal: :Critical Care 2009
Jorge Monserrat Raul de Pablo Eduardo Reyes David Díaz Hugo Barcenilla Manuel R Zapata Antonio De la Hera Alfredo Prieto Melchor Álvarez-Mon

INTRODUCTION Given the pivotal role of T lymphocytes in the immune system, patients with septic shock may show T cell abnormalities. We have characterised the T cell compartment in septic shock and assess its clinical implications. METHODS T lymphocytes from the peripheral blood of 52 patients with septic shock and 36 healthy control subjects were analysed on admission to the intensive care u...

Journal: :International immunology 2005
Masashi Watanabe Yasushi Hara Kazunari Tanabe Hiroshi Toma Ryo Abe

While the ligand of inducible co-stimulator (ICOS), B7 homologous protein, is widely expressed in somatic cells, B7-1 and B7-2 expression is mainly limited to lymphoid organs. Thus, the activation of T cells through ICOS without a CD28-mediated signal may occur in physiological situations. In order to gain a better understanding of the role of the ICOS co-stimulatory signal in immune responses,...

2012
Dorota Darmochwal-Kolarz Shigeru Saito Jacek Tabarkiewicz Bogdan Kolarz Jacek Rolinski Bozena Leszczynska-Gorzelak Jan Oleszczuk

The aim of our study was to estimate the surface expressions of CD95 (APO-1/Fas) antigen and the intracellular expressions of anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax in CD4(+)CD25(+)FoxP3(+) T regulatory lymphocytes (Tregs) as well as the percentage of CD8(+)CD28(+) T cytotoxic cells in peripheral blood of patients with pre-eclampsia in comparison with healthy pregnant women ...

2012
Yoshinori Sato Sayaka Nagata Masafumi Takiguchi

Humanized mice are expected to be useful as small animal models for in vivo studies on the pathogenesis of infectious diseases. However, it is well known that human CD8(+) T cells cannot differentiate into effector cells in immunodeficient mice transplanted with only human CD34(+) hematopoietic stem cells (HSCs), because human T cells are not educated by HLA in the mouse thymus. We here establi...

Journal: :Journal of immunology 2014
Shaun O'Brien Rajan M Thomas Gerald B Wertheim Fuqin Zhang Hao Shen Andrew D Wells

Naive CD4(+) T cells require signals from the TCR and CD28 to produce IL-2, expand, and differentiate. However, these same signals are not sufficient to induce autocrine IL-2 production by naive CD8(+) T cells, which require cytokines provided by other cell types to drive their differentiation. The basis for failed autocrine IL-2 production by activated CD8(+) cells is unclear. We find that Ika...

Journal: :Clinical & Experimental Immunology 1997

Journal: :Journal of immunology 2010
Henry Radziewicz Chris C Ibegbu Huiming Hon Nathalie Bédard Julie Bruneau Kimberly A Workowski Stuart J Knechtle Allan D Kirk Christian P Larsen Naglaa H Shoukry Arash Grakoui

Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective adaptive CD8(+) T cell immune responses. In addition to costimulatory signals, B7/CD28 family coinhibitory receptor/ligands that modulate immune responses have been identified. In acute hepatitis C virus (HCV) infection, programmed death receptor 1, an inhibitory receptor in the CD28 family, is highly expre...

Journal: :Blood 2001
P A Taylor C J Lees H Waldmann R J Noelle B R Blazar

The promotion of alloengraftment in the absence of global immune suppression and multiorgan toxicity is a major goal of transplantation. It is demonstrated that the infusion of a single modest bone marrow dosage in 200 cGy-irradiated recipients treated with anti-CD154 (anti-CD40L) monoclonal antibody (mAb) resulted in chimerism levels of 48%. Reducing irradiation to 100 or 50 cGy permitted 24% ...

Journal: :Blood 2003
Karin Elflein Marta Rodriguez-Palmero Thomas Kerkau Thomas Hünig

Slow recovery of T-cell numbers and function contributes to the high incidence of life-threatening infections after cytotoxic cancer therapies. We have tested the therapeutic potential of a novel class of superagonistic CD28-specific antibodies that induce polyclonal T-cell proliferation without T-cell receptor engagement in an experimental rat model of T lymphopenia. We show that in lethally i...

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