نتایج جستجو برای: cd8 cd28 regulatory t cells

تعداد نتایج: 2030475  

Journal: :iranian journal of basic medical sciences 0
ebrahim kouchaki department of neurology, kashan university of medical sciences, kashan, iran mahdi salehi student research committee, kashan university of medical sciences, kashan, iran mohammad reza sharif department of pediatrics, kashan university of medical sciences, kashan, iran hassan nikoueinejad nephrology and urology research center, baqiyatallah university of medical sciences, tehran, iran hossein akbari trauma research center, kashan university of medical sciences, kashan, iran

objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

Abtin Shahlaee Adel Sepanjnia Aliakbar Amirzargar, Fateme Pourrezagholi Mahboob Lessan Pezeshki Mahmoud Parvin Mohammad Hossein Nicknam Mohsen Nafar Pedram Ahmadpoor Sara Assadiasl

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Journal: :iranian journal of immunology 0
sara assadiasl department of immunology, school of medicine pedram ahmadpoor chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mohsen nafar chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mahboob lessan pezeshki nephrology research center, tehran university of medical sciences fateme pourrezagholi chronic kidney disease research center, labbafinejad hospital, shahid beheshti university of medical sciences mahmoud parvin department of pathology, labbafinejad hospital, shahid beheshti university of medical sciences, tehran, iran abtin shahlaee

background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...

Ebrahim Kouchaki Hassan Nikoueinejad, Hossein Akbari, Mahdi Salehi Mohammad Reza Sharif

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

Journal: :The Journal of clinical investigation 2003
Nader Najafian Tanuja Chitnis Alan D Salama Bing Zhu Christina Benou Xueli Yuan Michael R Clarkson Mohamed H Sayegh Samia J Khoury

CD8+ T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8-/-CD28-/- double-knockout mice are susceptible to EAE. These findings suggest a role for CD8+ T cells in the resistance of CD28-deficient mice to disease. Adoptive transfer of CD8+CD28- T cells into CD8-/- mice results in significant suppression of disease, while CD...

Journal: :Transplant immunology 2010
P Renner F C Popp E Eggenhofer P Slowik P Piso E K Geissler H J Schlitt M H Dahlke

The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immunomodulatory function of CD8(+)CD28(-) T cells requires antigen-specific TCR interaction with major histocompatibility complex class I (MHC I). We have isolated naïve CD8(+)CD28(-) T suppressor cells (Tsup) from H2-Kk Des-TCR mice that express a transgenic, MHC class ...

Journal: :Journal of leukocyte biology 2008
Rita Simone Anna Zicca Daniele Saverino

Aging is commonly associated with immune deficiency and dysregulation. The aging of the immune system involves a progressive reduction in naïve T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. We have investigated frequency, phenotype, and function of CD3+CD8+CD28(-)CD25+ T cells in healthy volunteers over a wide age range. We demonstrate t...

2017
Yirajen Vuddamalay Joost P. M. van Meerwijk

Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 1990s, research in the field of immune-regulation by various T cell populations has quickly gained momentum. While T cells expressing the transcription factor Foxp3 are currently in the spotlight, several other T cell populations endowed with potent immunomodulatory capacities have been identified in both the CD...

ژورنال: :مجله دانشکده پزشکی اصفهان 0
مهتاب تاپاک کارشناس ارشد، گروه ایمنی شناسی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران علیرضا عندلیب دانشیار، گروه ایمنی شناسی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران پیمان متقی دانشیار، گروه داخلی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران شادی بابازاده متخصص رادیوتراپی و انکولوژی، بیمارستان سیدالشهدا (ع)، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران عباس رضایی استاد، گروه ایمنی شناسی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران منصور ثالثی استادیار، گروه داخلی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

مقدمه: آرتریت روماتویید به عنوان بیماری th1 غالب تعریف می شود. سلول های tregs گروه جدیدی از سلول های t هستند که سایر سلول های اجرایی سیستم ایمنی از جمله th1 و th2 را تنظیم می کنند. foxp3 عامل توسعه و همچنین حفظ فعالیت مهاری سلول های treg است. در این مطالعه فراوانی سلول های cd4 + foxp3 + treg و cd8 + foxp3 + treg را در مبتلایان به آرتریت روماتویید بررسی کردیم. روش ها: نمونه ی خون محیطی از 31 بیم...

2014
Xuefen Li Haishen Kong Li Tian Qiaoyun Zhu Yiyin Wang Yuejiao Dong Qin Ni Yu Chen

Costimulatory signals are critical for antiviral immunity. The aim of this study was to evaluate the change of costimulatory molecule CD28 on circulating CD8+ T cells in chronic hepatitis B patients (CHB). Seventy CHB patients and fifty-six healthy controls were included, and forty-eight CHB patients were recruited for 52 weeks of longitudinal investigation. The proportions of circulating CD8+C...

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