Cytoplasmic dynein is a microtubule-based motor protein complex that plays important roles in a wide range of fundamental cellular processes, including vesicular transport, mitosis, and cell migration. A single major form of cytoplasmic dynein associates with membranous organelles, mitotic kinetochores, the mitotic and migratory cell cortex, centrosomes, and mRNA complexes. The ability of cytop...

We have demonstrated that the PEER cell line, which expresses a CD3-associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains can be synthesized by one cell line, and that these chains can independently associate with the CD...

Progenitor B lymphocytes that successfully assemble a heavy chain gene encoding an immunoglobulin capable of pairing with surrogate light chain proteins trigger their own further differentiation by signaling via the pre-BCR complex. The pre-BCR signals several rounds of proliferation and, in this expanded population, directs a complex, B cell-specific set of epigenetic changes resulting in alle...

A case of immunoglobulin G (kappa) myeloma showed, in addition to the monoclonal IgG(kappa) arc, two kappa chains in the serum. The urine specimen contained 7.75 g of kappa chains per liter. The electrophoretically fast-moving kappa chain in serum was shown by immunoelectrophoresis and Ouchterlony immunodiffusion to be a complex of kappa chains and alpha 1-antitrypsin. This complex, which was d...

In the paper weak sufficient conditions for the reduction of the chain complex of a twisted cartesian product F ×τ B to a chain complex of free finitely generated abelian groups are found.

We extend the combinatorial Morse complex construction to the arbitrary free chain complexes, and give a short, self-contained, and elementary proof of the quasi-isomorphism between the original chain complex and its Morse

Introduction: One of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. Aspirin (ASA) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. The aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

One of the most important points in a supply chain is customer-driven modeling, which reduces the bullwhip effect in the supply chain, as well as the costs of investment on the inventory and efficient transshipment of the products. Their homogeneity is reflected in the inventory-routing problem, which is a combination of distribution and inventory management. This paper considers a multi object...

In the petroleum supply chain, oil refined products are often delivered to distribution centers by pipelines since they provide the most reliable and economical mode of transportation over large distances. This paper addresses the optimal scheduling of a complex pipeline network with multiple branching lines. The main challenge is to find the optimal sequence and time of product injections/deli...