نتایج جستجو برای: chimeric antigen
تعداد نتایج: 216002 فیلتر نتایج به سال:
Immunotherapy for cancer treatment is growing at an unprecedented rate since the inception of chimeric antigen receptor T (CAR-T) cells. However, efficacy CAR-T cells against solid tumors hampered by various issues, including “on-target, off-tumor toxicities,” cell exhaustion, and immunosuppressive tumor microenvironment. To overcome these limitations, recent advances focus on optimizing using ...
To develop an effective vaccine against multiple genotypes of enterovirus 71 (EV71), we generated chimeric virus-like particles (VLPs) repetitively displaying the common neutralizing epitopes of EV71 and evaluated their immunogenicities in mice. The two conserved epitopes, encompassing amino acids 163-177 and 208-222 of VP1 of EV71, were fused to hepatitis B core antigen (HBcAg) and expressed i...
The bovine tick Rhipicephalus (Boophilus) microplus is found in several tropical and subtropical regions of the world. This parasite transmits pathogens that cause disease, such as babesiosis (Babesia bovis and B. bigemina) and anaplasmosis (Anaplasma marginale). Tick infestations cause enormous livestock losses, and controlling tick infestations and the transmission of tick-borne diseases rema...
Wild canids and domestic dogs are the main reservoir of zoonotic visceral leishmaniasis (VL) caused by Leishmania infantum (syn.: Leishmania chagasi). Serological diagnosis of VL is therefore important in both human and dog leishmaniasis from a clinical and epidemiological point of view. Routine diagnosis of VL is traditionally carried out by immunofluorescent antibody test (IFAT), which is lab...
The therapy with genetically modified T cells to express chimeric antigen receptors (CAR) is a promising strategy for immunotherapy against cancer. CAR-T can specifically recognize antigens on the surface of tumor and then effectively kill those cells. Several researchers have presented development various hematological targets treatment solid tumors. Quality control preclinical evaluation thes...
Immunotherapy is a rapidly developing field of multiple myeloma, disease which despite the development new drugs remains incurable. There are several antigens that being assessed in preclinical and clinical settings, but most studied all B-cell maturation antigen (BCMA). BCMA target for antibody conjugated with toxins (ADCs), bispecific engagers (BITEs), modified autologous lymphocytes (CAR-T, ...
CAR-Т cell therapy with the use of cytotoxic lymphocytes chimeric antigen receptors occupies an important place among modern approaches to cancer treatment. This has established itself as effective method treatment CD19+ acute lymphoblastic leukemia. Nevertheless, recurrences illness are not uncommon; solid tumors genetically engineered shows modest results and it is accompanied by high toxicit...
A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma Meenakshi Hegde, Zakaria Grada, Antonella Pignata, Amanda Wakefield, Kristen Fousek, Kevin Bielamowicz, Kevin Chow, Vita Brawley, Tiara Byrd, Stephen Gottschalk, Malini Mukherjee, Winfried S Wels, Matthew Baker, Giapietro Dotti, Jorda...
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