نتایج جستجو برای: chimeric antigen
تعداد نتایج: 216002 فیلتر نتایج به سال:
Background and purpose: Different genera of enterobacteriaceae have important roles in gastrointestinal diseases such as diarrhea. Among these, Enterotoxigenic E. coli (ETEC), enterohemorrhagic E. coli (EHEC), and Shigella are three main bacteria which are transmitted via contaminated food and water. Vaccination is a good strategy to combat these pathogens. In the present study, a chimeric anti...
background and objectives: the linear epitopes of gp46-i, gp46-ii, gp21 and p19 are used in diagnosis of htlv-i/-ii infections. the aims of this study was to obtain high-level expression and purification of recombinant antigen (ra) containing these epitopes. large-scale preparation of such antigen probably worths for diagnostic purpose. materials and methods: the synthetic dna encoding ra was s...
Introduction: To date, many vaccines have been developed for anthrax but not yet an ideal vaccine. In this study, chimeric protein containing domain 1 lethal factor and domain 4 protective antigens of Bacillus anthracis in copolymer nanocapsules were used to solve the problems caused by existing vaccines and to increase the efficiency of the proposed vaccine. Materials and Methods: In this expe...
hepatitis b surface antigen is the first genetically engineered vaccine licensed for human use. various strategies have been proposed to obtain a vaccine that would bypass the need for injection. in this study, a non-toxic portion of heat-stable enterotoxin of escherichia coli that is capable of adhering to epithelial cells was inserted at amino acid position 112 of hepatitis surface antigen. t...
Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR toxic effects in patients relapsed and refractory multiple myeloma.
We developed an immunogen to stimulate multivalent immunity against hepatitis B surface antigen (HBsAg) and hepatitis B core antigens (HBcAg). Immune responses specific for both HBsAg and HBcAg play an important role in controlling the infection. HBsAg-specific antibodies mediate elimination of virions at an early stage of infection and prevent the spread of virus. The immunogen was constructed...
computational tools are reliable alternatives to laborious work in chimeric protein design. in this study, a chimeric antigen was designed using computational techniques for simultaneous detection of anti-htlv-i and anti-hbv in infected sera. databases were searched for amino acid sequences of hbv/hlv-i diagnostic antigens. the immunodominant fragments were selected based on propensity scales. ...
Background and Objective: Harnessing immune system and its powerful arm, T lymphocytes, against tumor cells are yielding promising results in cancer immunotherapy. Using two arms of immune system in the designing of engineered T cells expressing chimeric receptors with anti-HER2 nanobody (camelid single domain antibody) seems to be an effective strategy in the targeted cancer therapy. ...
we developed an immunogen to stimulate multivalent immunity against hepatitis b surface antigen (hbsag) and hepatitis b core antigens (hbcag). immune responses specific for both hbsag and hbcag play an important role in controlling the infection. hbsag-specific antibodies mediate elimination of virions at an early stage of infection and prevent the spread of virus. the immunogen was constructed...
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell malignancies, and chimeric antigen receptor T cell therapy is now being investigated in several hematologic and solid tumor types. Chimeric antigen receptor T cells are generated by removing T cells from a patient's blood and engineering the cells to express the chimeric a...
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