The F344 rat carries alleles contributing to bone fragility while the GK rat spontaneously develops type-2 diabetes. These characteristics make F344×GK crosses well suited for the identification of genes related to bone size and allow for future investigation on the association with type-2 diabetes. The aim of this study was to identify quantitative trait loci (QTLs) for bone size phenotypes me...

The experience of childhood trauma (CT) and stressful life events (SLEs) is associated with subsequent development of a variety of mental health conditions, including psychotic illness. Recent research identifying adolescents and young adults at clinical high risk (CHR) for psychosis allows for prospective evaluation of the impact of trauma and adverse life events on psychosis onset and other o...

Hematological parameters, including red and white blood cell counts and hemoglobin concentration, are widely used clinical indicators of health and disease. These traits are tightly regulated in healthy individuals and are under genetic control. Mutations in key genes that affect hematological parameters have important phenotypic consequences, including multiple variants that affect susceptibil...

Genetic linkage maps play fundamental roles in understanding genome structure, explaining genome formation events during evolution, and discovering the genetic bases of important traits. A high-density cotton (Gossypium spp.) genetic map was developed using representative sets of simple sequence repeat (SSR) and the first public set of single nucleotide polymorphism (SNP) markers to genotype 18...

We have proposed a novel computation framework called Equivalent Transformation (ET). The ET framework is a rewriting system in which computation is executed by rewriting rules. Rewriting rules of the ET framework are called Equivalent Transformation Rules (ETRs). The theory of ET guarantees the correctness of the computation by ETRs. Multi-head ETRs which have multiple atoms in their head part...

Ulcerative colitis (UC) is characterized by a functional dysregulation of alternatively activated macrophage (AAM) and intestinal epithelial cells (IECs) homeostasis. Chromogranin-A (CHGA) secreted by neuroendocrine cells is implicated in intestinal inflammation and immune dysregulation. CHGA undergoes proteolytic processing to generate CHGA-derived peptides. Chromofungin (CHR: CHGA47-66) is a ...

To the Editor: We read with interest the article by Fernandez et al. Reticulocyte hemoglobin content (CHr) is a promising marker of iron metabolism, particularly in the intensive care unit setting where usual markers are often disrupted by inflammation. In a small cohort of critically ill patients with no evidence of real iron deficiency, we observed a correlation between C-reactive protein and...

To the Editor: We read with interest the article by Fernandez et al. Reticulocyte hemoglobin content (CHr) is a promising marker of iron metabolism, particularly in the intensive care unit setting where usual markers are often disrupted by inflammation. In a small cohort of critically ill patients with no evidence of real iron deficiency, we observed a correlation between C-reactive protein and...

Natalie Maag, Alemannische Minuskel (744 – 846 n. Chr.), Frühe Schriftkultur im Bodenseeraum und Voralpenland (Quellen Untersuchungen zur lateinischen Philologie des Mittelalters, Bd. 18), Stuttgart: Hiersemann 2014. XIV, 238 S. ISBN 978-3-7772-1422-1. Ln. € 164,–