The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. The genotype GA13-16 homozygote of the SH2D2A gene promoter has been associated with the susceptibility to develop multiple sclerosis. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy sharing several pathogenetic mechanisms with multip...

To the Editor Reply: We wish to thank Granata et al for their letter commenting on our article on hypertrophy of peripheral nerves in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that was detected by ultrasonography. We demonstrated a useful case which exemplifies the detection of segmental lesions of the peripheral nerves in CIDP by ultrasonography. We think that ultrasonog...

The discovery of the Guillain-Barré syndrome and related disorders Richard Hughes et al., London, United-Kingdom Pathophysiology of autoimmune polyneuropathies Marinos C. Dalakas, Athens, Greece Diagnosis, treatment and prognosis of Guillain-Barré syndrome (GBS) Pieter A. van Doorn, Rotterdam, The Netherlands Chronic inflammatory demyelinating polyradiculoneuropathy Peter Y.K. Van den Bergh, et...

A 59-year-old man died following a 20-year history of fulminant chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). His symptoms began with gait unsteadiness and ascending severe weakness and paresthesias, followed by papilledema and compressive cervical myelopathy from hypertrophic nerve roots (figure). Initial aggressive immunotherapy resulted in a return to ambulation and emplo...

We reviewed dinical, histological and ultrastructural findings of 124 cases of sural nerve biopsy specimens to delineate the trends of peripheral nerve diseases in our institute. Eighty-one were men and 43 were women. We categorized them into five groups: specific diagnosis (66 cases, 53.2%), axonal degeneration type (47 cases, 37.9%), demyelinating type (4 cases, 3.2%), mixed axonal degenerati...

Objective The objective of this study is to investigate whether chronic inflammatory demyelinating polyneuropathy (CIDP) and its subtypes differ in their type 1 T-helper (TH1) cell response against nodal/paranodal neurofascin (NF186, NF155) as well as myelin protein zero (P0 180-199) and myelin basic protein (MBP 82-100). Methods Interferon-gamma (IFN-γ) enzyme-linked immunospot assay was use...

Guillain-Barre syndrome (GBS) is an acute inflammatory demyelinating polyradiculoneuropathy that results from abnormal cell-mediated immune response to peripheral nerves. In about two-thirds of cases, infectious etiology precedes symptoms. GBS a rare disease during pregnancy with incidence 1.2 and 1.9 cases per 100,000 year carries high maternal risk. We report case complicating in the postpart...

We previously showed that heparan sulfate (HS) is required for in vitro cytokine + chemokine-mediated maintenance of primitive human hematopoietic progenitors. However, HS preparations are mixtures of polysaccharide chains of varying size, structure, and protein-binding abilities. Therefore, we examined whether the long-term culture-initiating cells (LTC-IC) supportive capability of HS is attri...