chronic inflammatory demyelinating polyneuropathy is an autoimmune disease with progressive and relapsing courses. the main clinical presentations are diffuse deep tendon hyporeflexia or areflexia and symmetric proximal-distal muscles weakness. myasthenia gravis is also an immune mediated disease with fluctuating ocular and bulbar symptoms and sometimes weakness. although both myasthenia gravis...

BACKGROUND Chronic inflammatory demyelinating polyradiculoneuropathy is a rare acquired immune-mediated progressive or relapsing disorder causing peripheral neuropathic disease of duration more than two months. Many individuals with chronic inflammatory demyelinating polyradiculoneuropathy fail to make a long-term recovery with current treatment regimes. The aim of this study was to prospective...

Inflammatory demyelinating polyradiculoneuropathy causes a spectrum of conditions ranging from acute (Guillain-Barré syndrome), through subacute to chronic forms. The pathogenesis of acute forms is related to antibody responses against glycolipid epitopes which mimic bacterial, especially Campylobacter jejuni, structures but T cells are also involved. The pathogenesis of chronic forms is poorly...

This scientific commentary refers to ‘Antibodies the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy’, by Pascual-Goñi et al. (doi:10.1093/brain/awab014).

The syndrome of acute inflammatory idiopathic polyneuropathy is well known, the predominently motor type of which is recognised by the name of Guillain-Barre Syndrome (GBS), in which the maximum neurological deficit develops rapidly in days, plateaus for weeks and then subsides with the recovery occurring in weeks to months. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) has e...

Peripheral neuropathies are among the most common diseases encountered in clinical neurology. Autoimmunity and inflammation are implicated in a small but important group of peripheral nerve disorders because they are potentially treatable. These include the acute inflammatory neuropathies grouped under Guillain-Barré syndrome (GBS) and the chronic inflammatory demyelinating polyradiculoneuropat...