نتایج جستجو برای: chronic myelogenous leukaemia
تعداد نتایج: 508249 فیلتر نتایج به سال:
A group of 82 adult patients with acute myelogenous leukaemia had survived in continuous first remission for more than three years was studied. These long-surviving patients were being treated at 12 referral centres in Europe and the USA, and they were compared with other patients with acute myelogenous leukaemia from 10 of these centres. There was no clear difference in the amount of induction...
• Structural aspects of the FLT3 receptor in signalling. Clonal evolution mutants. Recurrent mutations and its regulation signalling cascade drug therapy. Acute myelogenous leukaemia (AML) is an aggressive blood cancer characterized by rapid proliferation immature myeloid blast cells, resulting a high mortality rate. The 5-year overall survival rate for AML patients approximately 25%. Circa 35%...
Objective: To observe the K562 cell line derived from a patient of chronic myelogenous leukemia differentiated into megakaryocytes by growing in the presence of phorbol myristate
BACKGROUND & OBJECTIVES Chronic myelogenous leukaemia (CML) is the commonest leukaemia in Asia. There is a paucity data on cytogenetic and molecular analyses of Indian CML patients. This apparently reflects the low availability of cytogenetic and molecular techniques in our country. This study aimed to document various types of BCR-ABL fusion transcripts in different phases of CML and to compar...
Chronic myelogenous leukaemia (CML) is a clonal myeloproliferative disease which originates from primitive stem cells and is characterized by a reciprocal translocation between chromosomes 9 and 22. This results in generation of a chimeric gene (BCR/ABL) with increased tyrosine kinase activity. Such modifications cause CML-like myelopoiesis as has been recently demonstrated in mice [1]. Probabl...
The BCR-ABL protein is the causative agent in the pathogenesis of chronic myeloid leukemia (CML). Although there are several drugs in the market which inhibit BCR-ABL efficiently there are some cases of resistance1. Imatinib2,3, nilotinib3,4, bosutinib4 ,dasatinib5, bafetinib6 are approved tyrosine kinase inhibitors (TKI’s) and more recently, ponatinib was approved TKI which is shown to bind an...
Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...
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