with the present specifications for clasification, 95% of chronic myelogeneous leukaemia (cml) cases have the t(9;22), which brings the abl oncogene to the bcr region and results in a hybrid gene bcr/abl. there may be involvement of other chromosomes in 2-10%, and secondry or additional chromosome abberations may present in 60-80% during the progression of the disease. in the majority of the re...

8 Reiffers J, Goldman J, Meloni G, Cahn JY, Gratwohl A. Autologous stem cell transplantation in chronic myelogenous leukaemia: A retrospective analysis of the European Group of Bone Marrow Transplantation. Bone Marrow Transplanl1994; 14:407-10. 9 Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC. Long term marrow culture reveals chromosomally normal haematopoietic progenitor cells in patie...

Semiquantitative analysis of lactoferrin deficiency in neutrophil polymorphonuclear leucocytes in various haematological and non-haematological disease was carried out by scoring polymorphonuclear leucocytes stained for lactoferrin by the immunoperoxidase method. The staining patterns for lactoferrin were classified into four types (0-III) based on the intensity of reaction, and the sum of the ...

Evidence exists for the involvement of the most primitive and quiescent hematopoietic stem cell compartiment (CD34+/CD38-, Thy1+): t(9;22) is found in myeloid progenitor and in B-lymphocytes progenitors, but, involvement of the T-cell lineage is extremely rare. The existence of a highly quiescent stem cell population has been demonstrated in patients with CML. More recently, the presence of Ph ...

Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...

I Bullen AW, Gowland G, Rajah S, Losowsky MS. Hyposplenism, adult coeliac disease and autoimmunity. Gut 1981;22:28-33. 2 Brandt L, Mitelman F, Panani A, Lenner HC. Extremely long duration of chronic myeloid leukaemia with Ph negative and Ph positive bone marrow cells. Scand3'Haematol 1976;16:321-5. 3 Golde DW, Bersch NI, Sparkes RS. Chromosomal mosaicism associated with prolonged remission in c...

Life-threatening hypophosphataemia developed in a 47 year old woman with blastic crisis of chronic myelogenous leukaemia. The patient's hospitalization was characterized by reciprocal relationship between her white cell count and the serum phosphorus levels. The patient did not demonstrate any of the usual causes of profound hypophosphataemia. The postulated mechanism of this patient's hypophos...