This article introduces actuaries to the concept of "copulas," a tool for understanding relationships among multivariate outcomes. A copula is a function that links univariate marginals to their full multivariate distribution. Copulas were introduced in 1959 in the context of probabilistic metric spaces. Recently, there has been a rapidly developing literature on the statistical properties and ...

introduction: the aim of the present in vitro study was to compare the accuracy of cone-beam computed tomography (cbct) in determining root canal morphology of mandibular first molars in comparison with staining and clearing technique. methods and materials: cbct images were taken from 96 extracted human mandibular first molars and the teeth were then evaluated based on vertucci’s classificatio...

In scattering specimens, multiphoton excitation and nondescanned detection improve imaging depth by a factor of 2 or more over confocal microscopy; however, imaging depth is still limited by scattering. We applied the concept of clearing to deep tissue imaging of highly scattering specimens. Clearing is a remarkably effective approach to improving image quality at depth using either confocal or...

It was recently shown in this laboratory (1) that in idiopathic hyperlipemia the elimination of lipids from the blood stream following an intravenous infusion of a fat emulsion is considerably delayed, indicating a defect of the lipemiaclearing mechanism in these patients. It was then found that the clearing activity present in the serum of normal human subjects who have received heparin was in...

1.1 Figure 1 of Annex A plots data for the 301 PCTs out of the 303 listed in the Department of Health’s document for which figures are available for both axes. The y-axis is the (presumably cumulative) surplus (negative if deficit) by the end of 2004-05, expressed as a percentage of the 2004-05 turnover. The x-axis is the PCT’s target index for the period 2003/6, defined as the (per capita) rat...

In situ, cells of the musculoskeletal system reside within complex and often interconnected 3-D environments. Key to better understanding how 3-D tissue and cellular environments regulate musculoskeletal physiology, homeostasis, and health is the use of robust methodologies for directly visualizing cell-cell and cell-matrix architecture in situ. However, the use of standard optical imaging tech...

Callery pear ( Pyrus calleryana ) is an invasive tree across much of the eastern United States that can form dense thickets, and branches stems are often covered in sharp thorns. Landowners land managers attempting to manage callery infestations faced with challenge killing and/or removing trees while also avoiding thorn damage equipment, which lead wasted time increased costs. We evaluated fir...

The debts’ clearing problem is about clearing all the debts in a group of n entities (persons, companies etc.) using a minimal number of money transaction operations. The problem is known to be NP-hard in the strong sense. As for many intractable problems, techniques from the field of artificial intelligence are useful in finding solutions close to optimum for large inputs. An evolutionary algo...