STATEMENT OF PROBLEM Fabricating a feldspathic porcelain margin on a metal-ceramic restoration with a clinically acceptable marginal fit has proven to be a technique-sensitive procedure. Pressable ceramics are advocated to solve this problem. PURPOSE The purpose of this in vitro study was to compare the marginal adaptation of a pressable ceramic system when used with both all-ceramic and meta...

To identify genetic changes involved in the progression of breast carcinoma, we did cDNA array comparative genomic hybridization (CGH) on a panel of breast tumors, including 10 ductal carcinoma in situ (DCIS), 18 invasive breast carcinomas, and two lymph node metastases. We identified 49 minimal commonly amplified regions (MCRs) that included known (1q, 8q24, 11q13, 17q21-q23, and 20q13) and se...

Protein-protein interactions (PPIs) are broadly recognized as an emerging target class for a whole new era in drug discovery. They show significant differences to classical target classes and have been regarded as “undruggable” for a long time. Priaxon AG has developed a unique, proprietary technology platform for PPI drug discovery. PriaXplore employs novel computational and synthetic approach...

haemovigilance is a system with standard program to cover the entire transfusion chain, monitor, evaluate and analyse the data to improve patients’ safety. we report the implemented haemovigilance system in hospitals and transfusion reactions (tr) in iran. methods and materials: this was a prospective descriptive study. the national reporting system for transfusion incidents was introduced in j...

The rapid development of science and technology has brought urgent demand for diversity in polymer structures functionalities, the pursuit new polymerizations is constant goal chemistry. Multicomponent reactions (MCRs)—reactions three or more starting materials able to generate a single product one-pot manner—feature series advantages such as simple reactants, easy operation, mild conditions, h...

The realization of lithium-oxygen (Li-O2) batteries has been impeded by parasitic reactions that cause cell component degradation, often accompanied the release CO2 gas during oxidation reactions. use...

Due to increasing rates of obesity and its comorbidities, there is tremendous interest in the central nervous system (CNS) control of energy balance. This basic science interest is guided in part by the need to develop effective drugs for the overweight and the obese patient. Despite a large literature, our understanding of the circuits and neurochemical receptors that mediate energy balance is...

An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...