Oxidative modification of low-density lipoproteins (LDL) contributes to the pathology of atherosclerosis. Antioxidants may protect LDL against oxidative modification. Acetaminophen, a widely used analgesic and antipyretic agent, has significant antioxidant properties. However, there is little evidence to suggest that acetaminophen acts as an antioxidant for LDL oxidation in vivo. In this study,...

Significantly increased aCtlVlfY of Cr(CO)6 was achieved for the stereoselective homogeneous hydrogenation of methyl sorbate and tmns,trans-conjugated fatty esters at ambient temperature and pressure by exposing the catalyst to UV irradiation (3500.'1.) in a solvent mixture of cyclohexane-acetonitrile (20:1). In this solvent mixture, methyl sorb ate was converted quantitatively at ambient condi...

We present a compilation of methodologies developed in our laboratories to assemble polycyclic structures containing smalland medium-sized cycles, relying on the use of transition-metal-catalyzed (TMC) cycloadditions. First, we discuss the use of alkylidene cyclopropanes (ACPs) as 3C-atom partners, in particular in their Pd-catalyzed (3 + 2) cycloadditions with alkynes, alkenes, and allenes, re...

Lipid oxidation is the main hurdle for omega-3 fatty acid enrichment in food and beverages. Fat reduces quality safety of supplemented products. A tuna oil-in-water emulsion (20% v/v) was exposed to iron-induced oxidation. Emulsions with changing emulsifiers buffers were analyzed under different storage conditions (argon purging, pH variation) using Conjugated Dienes Thiobarbituric reactive sub...

Homocoupling reactions of aryl, alkenyl, and alkynyl Grignard reagents are an easy and efficient access to symmetrical dior polyaromatic, olefinic, or acetylenic conjugated compounds. The potential applications of such compounds in optical materials, molecular devices, and organic conductors are well-recognized.1 Therefore, for large-scale applications, it is interesting to develop more conveni...