The aim of the study was to evaluate the role of HLA-DRB1 (Human Leukocyte Antigens) matching in corneal transplantation. Fifty-two patients were observed. Low-risk group consisted of 28 patients and high-risk group consisted of 24 patients. All the patients and donors were tissue typed with Polymerase Chain Reaction (PCR) on the HLA-DRB1 gen. The primary corneal disease preceding keratoplasty ...

PURPOSE Due to its ability to disrupt transforming growth factor beta (TGF-β) signaling, halofuginone has been successfully used to treat various fibrotic disorders. Here we investigated the antifibrotic potential of halofuginone in human corneal fibroblasts. METHODS Human corneal fibroblasts were isolated from human donor corneas for in vitro experiments. TGF-β was used to stimulate pro-fibr...

Corneal keratocyte apoptosis triggered by cornel debridement is one mechanism of corneal disorders. In this study, the feasibility of cyclo-(d-Trp-Tyr) peptide nanotubes (PNTs) as carriers of caspase 3 silence shRNA delivery was assessed. A model of epithelial injury by epithelial debridement was applied to investigate the feasibility of PNTs as gene delivery carriers on corneal injury. First, ...

Neurofibromatosis type 2 (NF2) is a genetically determined tumor-predisposing syndrome. Ocular manifestations include cataracts, epiretinal membranes, retinal hamartomas, optic disk gliomas, and nerve sheath meningiomas. Moreover, edema, optical atrophy, motility disorders, pupil lid dysfunction, neurotrophic keratitis can be observed as indirect signs. An observational study was conducted with...

I read the article titled " Fine needle diathermy – A choice for managing corneal vascularization " and written by Thatte S (2011) with great interest as corneal vascularization is a very common problem encountered by us also in Nepal. Most of the cases that we see are healed corneal ulcers with vascularization, in which doing an optical keratoplasty is a big challenge. The author has done a ve...

purpose : to report a case of recurrent corneal intrastromal cyst containing lymph fluid case report : a 13-year-old girl presented with recurrent cyst of the left cornea, which had been drained three years before, but had gradually recurred. the cyst was successfully drained. histologic examination, cytologic analysis, and protein electrophoresis were performed on the cyst fluid. histopatholog...

patients with keratoconus constitute a large proportion of patients suffering from anterior segment disorders. as of this time, however, its pathogenesis has not yet been elucidated. a reduction in cross-link between collagen molecules has been observed in keratoconic eyes as compared to normal ones. present approaches only address refractive errors resulting from the abnormal abnormal corneal ...

Globally, approximately 75% of blind children live in low-income countries (LICs). Almost half of blindness and low vision in LICs is due to avoidable causes such as corneal scarring from measles infection, vitamin A deficiency disorders, use of harmful traditional eye remedies, ophthalmia neonatorum and cataract.

Vernal keratoconjunctivitis (VKC), a severe form of ocular allergic disease, is characterized by the formation of giant papillae at the upper tarsal conjunctiva and corneal lesions that threaten vision. Recent evidence indicates that resident fibroblasts function as immune modulators in the pathogenesis of the chronic allergic inflammation associated with VKC. The T helper 2 (Th2) cell-derived ...