introduction: repetitive cortical spreading depression (csd) can lead to cell death in immature brain tissue. caspases are involved in neuronal cell death in several csd-related neurological disorders. yet, whether repetitive csd itself can induce caspase activation in adult or juvenile tissue remains unknown. inducing repetitive csd in somatosensory cortices of juvenile and adult rats in vivo,...

conclusions the outside diameter/inside diameter ratio at the metaphyseal/diaphyseal junction of the distal radius on ap radiographs is suitable for use as a predictor of distal-radius bone density. further studies should be performed, and clinical utility evaluated. results the mean bmd was 0.559 (sd = 0.236) g / cm2. the mean outside diameter/inside diameter ratio was 1.24 (sd = 0.013); the r...

Brock AA, Friedman RM, Fan RH, Roe AW. Optical imaging of cortical networks via intracortical microstimulation. J Neurophysiol 110: 2670 –2678, 2013. First published September 11, 2013; doi:10.1152/jn.00879.2012.—Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is kno...

The objectives of this study were to characterize the auditory cortex response in the rat and to examine its contributions to the auditory evoked potentials (AEPs) recorded from the dorsal and lateral skull. This was accomplished by simultaneously recording AEPs from the cortical surface and from skull screw electrodes in anesthetized animals. The initial positive-negative response (P17-N32) wa...

Autism has been described as a disorder of general neural processing, but the particular processing characteristics that might be abnormal in autism have mostly remained obscure. Here, we present evidence of one such characteristic: poor evoked response reliability. We compared cortical response amplitude and reliability (consistency across trials) in visual, auditory, and somatosensory cortice...

Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predic...

conclusions the most effected parts in asd are lateral connections of hmasd. two-sided connections which are completely symmetric become more active, and cause extra synchronization. on the other hand, due to special characteristic of two-sided connections and their ability to simulate the same phased dynamics, they cause unnatural asymmetry in children’s eeg signal. these results are consisten...

INTRODUCTION Response latencies of cortical neurons are not inexorably linked to response magnitude (Oram and Perrett 1992; Gawne et al 1996). The response latency of striate cortical neurons is heavily influenced by contrast whereas changes in response magnitude induced by changes in stimulus configuration (orientation) have relatively less effect on response latency. LGN neurons show increase...

Understanding cortical organization is key to understanding brain function. Distinct neural networks underlie the functional organization of the cerebral cortex; however, little is known about how different nodes in the cortical network interact during perceptual processing and motor behavior. To study cortical network function we examined whether the optical imaging of intrinsic signals (OIS) ...