نتایج جستجو برای: cox hazard function
تعداد نتایج: 1301063 فیلتر نتایج به سال:
BACKGROUND Long-acting beta-agonists were one of the first-choice bronchodilator agents for stable chronic obstructive pulmonary disease. But the impact of long-acting beta-agonists on mortality was not well investigated. METHODS National Emphysema Treatment Trial provided the data. Severe and very severe stable chronic obstructive pulmonary disease patients who were eligible for volume reduc...
BACKGROUND Preclinical studies suggest that opioids may promote tumor growth. Genetic polymorphisms have been shown to affect opioid receptor function and to modify the clinical effects of morphine. In this study we assessed the association between six common polymorphisms in the μ-opioid receptor gene, including the well known A118G polymorphism, and breast cancer survival. METHODS A total o...
BACKGROUND Oral corticosteroids were used to control stable chronic obstructive pulmonary disease (COPD) decades ago. However, recent guidelines do not recommend long-term oral corticosteroids (LTOC) use for stable COPD patients, partly because it causes side-effects such as respiratory muscle deterioration and immunosuppression. Nonetheless, the impact of LTOC on life prognosis for stable COPD...
We analyze the e¤ects of family ties on the incentives for production of e¤ort, where family ties are de ned as a mixture of true and coerced altruism between family members. We model families as pairs of siblings. Each sibling exerts e¤ort in order to obtain output under uncertainty. A social norm dictates that a sibling with a high output must share a speci ed amount of this output with his s...
BACKGROUND An inverse relationship between experience and risk of injury has been observed in many occupations. Due to statistical challenges, however, it has been difficult to characterize the role of experience on the hazard of injury. In particular, because the time observed up to injury is equivalent to the amount of experience accumulated, the baseline hazard of injury becomes the main par...
BACKGROUND Rod failure has been reported clinically in pedicle subtraction osteotomy (PSO) to correct flat back deformity. OBJECTIVE To characterize the fatigue life of posterior screw-rod constructs in the setting of PSO as a function of the severity of rod contour angle. METHODS A modified ASTM F1717 to 04 was used. Rods were contoured to the appropriate angle for the equivalent 20-, 40-,...
The purpose of this article is to provide an adaptive estimator of the baseline function in the Cox model with high-dimensional covariates. We consider a two-step procedure : first, we estimate the regression parameter of the Cox model via a Lasso procedure based on the partial log-likelihood, secondly, we plug this Lasso estimator into a least-squares type criterion and then perform a model se...
INTRODUCTION Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simplified RIFLE (risk, injury, failure, loss of kidney function, and end-stage re...
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