نتایج جستجو برای: cox i
تعداد نتایج: 1084140 فیلتر نتایج به سال:
PURPOSE To investigate the effect of the inflammatory mediator platelet-activating factor (PAF) in the induction of the inducible prostaglandin H synthase-cyclooxygenase-2 (COX-2) gene expression in corneal epithelium. METHODS Rabbit corneas were incubated in organ culture with or without carbamyl PAF (cPAF, 100 nM). The effects of PAF antagonist BN50730 (10 microM), protein synthesis inhibit...
Background and objective: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer. Mater...
مهم ترین راهبرد در طراحی ترکیبات ضد التهابی قوی با کاهش قابل توجه اثرات جانبی، بازداری انتخابی آنزیم سیکلواکسیژناز-2 (cox-2) است. در پژوهش حاضر مطالعات qsar با استفاده از توصیف کننده های مولکولی مختلف سعی در کشف ساختار و خواص فیزیکوشیمیایی مشتقات پیرازولین به عنوان بازدارنده های cox-2 را دارد. ساختارهای سه بعدی 23 تا از مشتقات پیرازولین توسط روش نیمه تجربی am1 در نرم افزار hyperchem بهینه شدند....
We report a cytochrome c oxidase (COX)-deficient patient, clinically affected with Leigh-like disease, with a homozygous mutation in the COX10 start codon. Two-dimensional gel electrophoresis showed a decrease of fully assembled COX without the accumulation of partially assembled COX subcomplexes. Western blot analysis with antibodies directed to COX subunits I, II, and IV showed a decrease of ...
BACKGROUND Elevated Cyclooxygenase-2 (COX-2) expression is thought to increase metastatic potential of many tumors. Furthermore, elevated COX-2 expression correlates with radiation resistance in many tumor types. We evaluated whether: (i) the degree of COX-2 expression correlated with either metastatic tumor type or with the presence of necrosis and whether (ii) radiation-resistant tumors (rena...
Neoangiogenesis may have an important role in the poor prognosis of gallbladder carcinoma. An enhanced expression of COX- was found in precancerous lesions and in gallbladder carcinoma, likely to be involved in carcinogenesis as well as in angiogenesis. To study the relationships between the COX- expression and degree of vascularization, as well as to evaluate their role in the prognosis of p...
Background & Objectives: Cox regression model is one of the statistical methods in survival analysis. The use of smoothing techniques in Cox model makes the more accurate estimates for the parameters. Fractional polynomial is one of these techniques in Cox model. The aim of this study was to assess the effects of prognostic factors on survival of patients with gastric cancer using the fractiona...
background and objective: egfr and her-2 are two members of erbb/her family of type i transmembrane growth factor receptors. cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. the aim of this study was to determine the level of expression of egfr, her-2 and cox2 in colorectd cancer. mater...
We report the synthesis and evaluation of a series of iodinated celecoxib analogues as cyclooxygenase-2 (COX-2)-targeted single photon emission computerized tomography (SPECT) imaging agents for the detection of inflammation. The structure-activity relationship identified 5-(4-iodophenyl)-1-{4-(methylsulfonyl)phenyl}-3-(trifluoromethyl)-1H-pyrazole (8) as a promising compound with IC(50) values...
The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients.The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoA-I],...
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