Purpose: To investigate the effect of S-adenosyl-L-methionine (SAM) on angiogenesis and fibrosis in heart rats with myocardial infarction (MI), to determine mechanism action.Methods: Sprague Dawley MI received SAM treatment (15 mg/kg) intraperitoneally. The cumulative survival (%) was recorded their rate survival. Hematoxylin-eosin staining, echocardiography, hemodynamics were also performed. I...

Deployment-related exposures to organophosphate (OP) compounds are implicated for Gulf War Illness (GWI) development in First GW veterans. However, reasons the persistence of GWI not fully understood. Epigenetic modifications chromatin regulatory mechanisms that can adaptively or maladaptively respond external stimuli. These include DNA methylation and histone acetylation. changes have been rep...

We have examined the effects of pre-hepatic portal hypertension on the responsiveness of aorta from Wistar and Sprague-Dawley rats. Rats were made portal hypertensive by creating a calibrated portal vein stenosis, or sham operated. In rat aorta, there was no significant difference between portal hypertensive and sham-operated animals in the contractile potency of KCl, noradrenaline or phenyleph...

Background: Urinary tract infection in children may cause renal scar formation, which can be prevented by early and appropriate treatment. Recent studies showed that single daily injection of gentamycin can produce best effect without increasing the side effects. The aim of this study was to evaluate the rate of renal scar formation when new regime (every other day gentamicin injection) used fo...

Abstract Dimethylbenzantracene is a compound that radical reactive, genotoxic, and immunotoxic. Black cumin seeds have antioxidative properties. The study aimed to determine the effect of black seed ethanolic extract as an antioxidant by observing secretion activity ROI NO peritoneal macrophages in Sprague Dawley (SD) rats induced DMBA. This controlled experiment used 30 male SD rats. test anim...

Studies with angiotensin (Ang) II type 1 receptor blockers suggest that the brain renin-angiotensin system contributes to sodium-induced sympathoexcitation and hypertension. To provide more specific evidence for the involvement of Ang II, locally produced in the brain, transgenic rats were used, which express an antisense RNA against angiotensinogen mRNA specifically in the brain, reducing angi...

The probability of structural remodeling in brain circuits may be modulated by molecules perineuronal nets (PNNs) that restrict neuronal plasticity to stabilize circuits. Animal research demonstrates addictive drugs can remodel PNNs different regions, including the cerebellum. This study aimed investigate effects short versus extended access cocaine self-administration on PNN expression around ...

Qualitative and quantitative differences of purified hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase were investigated in Wistar and Sprague-Dawley rats. Individual differences in the glucuronidation rate of androsterone and chenodeoxycholic acid were observed in hepatic microsomal fractions from Wistar but not Sprague-Dawley rats. No individual variation was observed in the glucuron...

Clotting abnormalities are discussed both in the context with thyroid dysfunctions and obesity caused by a high fat diet. This study aimed to investigate the impact of hypo-, or hyperthyroidism on the endogenous thrombin potential (ETP), a master indicator of clotting activation, on Sprague Dawley rats fed a normal or high fat diet. Female Sprague Dawley rats (n = 66) were grouped into normal d...