BACKGROUND Although endoscopic submucosal dissection (ESD) is routinely performed under sedation, the difference in ESD performance according to sedation method is not well known. This study attempted to prospectively assess and compare the satisfaction of the endoscopists and patient stability during ESD between two sedation methods. METHODS One hundred and fifty-four adult patients schedule...

OBJECTIVE To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. DESIGN Pilot prospective, multicenter, randomized, controlled trial. SETTING Six ICUs. PATIENTS Critically ill adults mechanically ventilated for greater than 24 hours. INTERVENTIONS Patients randomized to early goal-directed sedation received a dexmedetomidine-base...

BACKGROUND Safe care of sedated children requires ongoing assessment of the depth of sedation to permit early recognition of progression to over-sedation. This study evaluated the validity and reliability of the University of Michigan Sedation Scale (UMSS) as a measure of sedation during procedures. The UMSS is a simple observational tool that assesses the level of alertness on a five-point sca...

The field of pediatric sedation and analgesia has evolved over the past two decades. The growing number of pediatric gastrointestinal endoscopy procedures requiring sedation and analgesia are recognized even in developing countries. It is well accepted that children undergoing diagnostic and therapeutic gastrointestinal endoscopic procedures should receive sedation and/or anesthesia. Neverthele...

Vera VUČIĆEVIĆ Center for Anesthesiology and Reanimatology Clinical Center of Serbia Višegradska 26 11000 Belgrade Serbia [email protected] SUMMARY Introduction There is an increasing interest in balanced propofol sedation (BPS) for colonoscopy in outpatient settings. Propofol is a potent anesthetic agent for this purpose and has a narrow therapeutic range, which increases a risk of ca...

BACKGROUND Pulmonary vein antrum isolation (PVAI) under sedation has proven to be a useful strategy for catheter ablation of atrial fibrillation (AF). METHODS To evaluate the clinical benefits of respiratory management using supraglottic airways (SGAs) under deep sedation while monitoring the bispectral (BIS) index during the PVAI and the durations from admission to the catheterization room t...

The levels of sedation required for patients to comfortably undergo colonoscopy with propofol were examined. One hundred patients undergoing colonoscopy with propofol were enrolled. In addition to standard-of-care monitoring, sedation level was monitored with the Patient State Index (PSI) obtained from a brain function monitor, transcutaneous carbon dioxide (tcpCO2) was monitored with the TCM T...

Environmental events are processed on multiple timescales via hierarchical organization of temporal receptive windows (TRWs) in the brain. The dependence of neural timescales and TRWs on altered states of consciousness is unclear. States of reduced consciousness are marked by a shift toward slowing of neural dynamics (<1 Hz) in EEG/ECoG signals. We hypothesize that such prolongation of intrinsi...

A combination of drugs may be preferred over the use of a single agent to induce deep sedation. A synergistic interaction between the drugs reduces the dose requirements of the drugs thereby minimising the unwanted side effects associated with each drug and improving recovery. The present study was undertaken to evaluate the suitability of dexmedetomidine and dexmedetomidine in combination with...