Background: Pediatric oncology patients frequently need several painful procedures during their diagnostic and therapeutic process. During the past decades, most centers abroad have developed safe and effective protocols for procedural sedation and analgesia in children. This report describes procedural sedation and analgesia as performed in pediatric oncology unit and tries to report success o...

Published literature has not discerned end-of-life palliative versus life-shortening effects of pharmacologically maintaining continuous deep sedation until death (i.e., dying in deep sleep) compared with common sedation practices relieving distress in the final conscious phase of dying. Continuous deep sedation predictably suppresses brainstem vital centers and shortens life. Continuous deep s...

INTRODUCTION There is increasing evidence that deep sedation is detrimental to critically ill patients. The aim of this study was to examine effects of deep sedation during the early period after ICU admission on short- and long-term survival. METHODS In this observational, matched-pair analysis, patients receiving mechanical ventilation that were admitted to ICUs of a tertiary university hos...

CONTEXT Existing empirical evidence shows that continuous deep sedation until death is given in about 15% of all deaths in Flanders, Belgium (BE), 8% in The Netherlands (NL), and 17% in the U.K. OBJECTIVES This study compares characteristics of continuous deep sedation to explain these varying frequencies. METHODS In Flanders, BE (2007) and NL (2005), death certificate studies were conducte...

background: pediatric oncology patients frequently need several painful procedures during their diagnostic and therapeutic process. during the past decades, most centers abroad have developed safe and effective protocols for procedural sedation and analgesia in children. this report describes procedural sedation and analgesia as performed in pediatric oncology unit and tries to report success o...

Moderate and deep sedation can be provided using various classes of drugs, each having unique mechanisms of action. While drugs within a given classification share similar mechanisms and effects, certain classes demonstrate superior efficacy but added concern regarding safety. This continuing education article will highlight essential principles of pharmacodynamics and apply these to drugs comm...

BACKGROUND/AIMS The use of moderate to deep sedation for gastrointestinal endoscopic procedures has increased in Europe considerably. Because this level of sedation is a risky medical procedure, a number of international guidelines have been developed. This survey aims to review if, and if so which, quality aspects have been included in new sedation practices when compared to traditional uncont...

conclusions propofol provided a safe and acceptable sedation for post-cabg surgical patients, significantly reduced the requirement for analgesics, and allowed for more rapid tracheal extubation than midazolam but did not result in earlier icu discharge. results the depth of sedation was almost the same in the two groups (rss=4.5 in midazolam group vs 4.7 in propofol group; p = 0.259) but the t...

BACKGROUND Genetically engineered mouse models of human cardiovascular disease provide an opportunity to understand critical pathophysiological mechanisms. Cardiovascular magnetic resonance (CMR) provides precise reproducible assessment of cardiac structure and function, but, in contrast to echocardiography, requires that the animal be immobilized during image acquisition. General anesthetic re...