Human pulmonary alveolar macrophages obtained by bronchoalveolar lavage from both normal controls and smokers secreted in vitro a neutral proteinase that degraded denatured collagens. Optimal expression of the proteinase was detected after 3-5 d of culture. The proteinase could not be detected in the media of cultures that had been treated with 0.5 gg/ml of cycloheximide. The gelatinase had an ...

PURPOSE To explore the possible intermediary pathways through which diabetes mellitus (DM) adversely worsens hepatocellular carcinoma (HCC), focusing on cell life controllers as some transcription factors and inflammatory mediators. MATERIAL AND METHODS Forty male albino rats were divided into four groups, control, cancer [given single intra-peritoneal (IP) dose of diethyl nitrosamine, NDEA, ...

The title mol-ecule, [Zn(2)(C(8)H(8)NO(2))(4)(C(10)H(14)N(2)O)(2)]·2H(2)O, is a centrosymmetric binuclear complex, with two Zn(II) ions [Zn⋯Zn' = 2.9301 (4) Å] bridged by four methyl-amino-benzoate (MAB) ligands. The four nearest O atoms around each Zn(II) ion form a distorted square-planar arrangement with the distorted square-pyramidal coordination completed by the pyridine N atom of the N,N-...

BACKGROUND & AIMS gp96, or grp94, is an endoplasmic reticulum (ER)-localized heat shock protein 90 paralog that acts as a protein chaperone and plays an important role for example in ER homeostasis, ER stress, Wnt and integrin signaling, and calcium homeostasis, which are vital processes in oncogenesis. However, the cancer-intrinsic function of gp96 remains controversial. METHODS We studied t...

Arnasbideetako infekzioek heriotza tasa altuak eragiten dituzte munduan, COVID-19 birusa izanik azken urteetako adibiderik argiena. Hala ere, ez da libre dabilen patogeno bakarra eta berrikuspen honetan Bordetella pertussis bakterio patogenoak eragindako kukutxeztulaz arituko gara. Kukutxeztula arnasbideen infekzio larri kutsakorra da, bertako jariakinekin edota listu tantekin kontaktua izatean...

Modu zirkularrean polarizatuta dagoen argia xurgatzeko eta batez ere igortzeko gai diren molekula zein material kiralen garapena egungo gaia da kimikan materialen zientzietan. Izan ere, biomolekula ugari kiralak dira horien portaera nabarmen aldatzen enantiomeroaren arabera. Hori dela eta, argi polarizatu horrekin lortzen den sentikortasuna bereizmena ez-polarizatuarekin dena baino handiagoa da...

In the centrosymmetric binuclear title complex, [Co(2)(C(11)H(14)NO(2))(4)(C(10)H(14)N(2)O)(2)], the two Co(II) cations [Co⋯Co = 2.6199 (5) Å] are bridged by four 4-(diethyl-amino)-benzoate (DEAB) anions. The four nearest O atoms around each Co(II) ion form a distorted square-planar arrangement, the distorted square-pyramidal coordination geometry being completed by the pyridine N atom of an N,...

Beben Benyamin1,2, Tonu Esko3,4, Janina S. Ried5, Aparna Radhakrishnan6, Sita H. Vermeulen7,8, Michela Traglia9,10, Martin Gögele11, Denise Anderson12, Linda Broer13,14, Clara Podmore15, Jiańan Luan15, Zoltan Kutalik16,17, Serena Sanna18, Peter van der Meer19, Toshiko Tanaka20, Fudi Wang21, Harm-Jan Westra22, Lude Franke22, Evelin Mihailov3,23, Lili Milani3, Jonas Hälldin3, Juliane Winkelmann24...

Brian H. Chen, Riccardo E. Marioni, Elena Colicino, Marjolein J. Peters, Cavin K. Ward‐ Caviness, Pei‐Chien Tsai, Nicholas S. Roetker, Allan C. Just, Ellen W. Demerath, Weihua Guan, Jan Bressler, Myriam Fornage, Stephanie Studenski, Amy R. Vandiver, Ann Zenobia Moore, Toshiko Tanaka, Douglas P. Kiel, Liming Liang, Pantel Vokonas, Joel Schwartz, Kathryn L. Lunetta, Joanne M. Murabito, Stefania B...