This study examines the phenomena of the hormone-active fibers obtaining process, in the form of artificial insulin depot. As a fibrous carrier of insulin cation-exchange polyacrylonitrile (PAN) fibers and biodegradable polysaccharide alginate fibers were used. The process of obtaining fibrous artificial insulin depot was based on the chemisorption of insulin from insulin aqueous solutions by t...

Abstract: The Open Vehicle Routing Problem (OVRP) is one of the most important extensions of the vehicle routing problem (VRP) that has many applications in industrial and service. In the VRP, a set of customers with a specified demand of goods are given and a depot where a fleet of identical capacitated vehicles is located. We are also given the ‘‘traveling costs’’ between the depot and all th...

Abstract In this paper, we study the multi-depot k -traveling repairman problem. This problem extends traditional traveling to case. Its objective, similar single depot variant, is minimization of sum arrival times customers. We propose two distinct formulations model problem, obtained on layered graphs. order find feasible solutions for largest instances, a hybrid genetic algorithm where initi...

We introduce the multimodal car- and ride-sharing problem (MMCRP), in which a pool of cars is used to cover set ride requests while uncovered are assigned other modes transport (MOT). A car’s route consists one or more trips. Each trip must have specific but non-predetermined driver, start depot finish (possibly different) depot. Ride-sharing between users allowed, even when two rides do not sa...

Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemica...

In humans, adipose tissue is distributed in subcutaneous abdominal and subcutaneous gluteal depots that comprise a variety of functional differences. Whereas energy storage in gluteal adipose tissue has been shown to mediate a protective effect, an increase of abdominal adipose tissue is associated with metabolic disorders. However, the molecular basis of depot-specific characteristics is not c...