Cancer is the second leading cause of death worldwide. Despite great efforts over many years, today cancer treatment is not very effective. The main reasons for cancer chemotherapy failure are high cytotoxicity, low response rates in solid tumors, and development of resistance. Different experimental studies have shown that drug combination using low toxicity natural compounds such as polypheno...

Silymarin, which derived from the milk thistle plant (silybum marianum), has been used for centuries as a natural remedy for diseases of the liver and biliary tract. Considering the therapeutic potential to liver disease, we tested efficacy of silymarin on hepatic steatosis with a high fat diet (HFD)-induced mouse model of non-alcoholic fatty liver disease (NAFLD), and investigated possible eff...

Silibinin, derived from the milk thistle plant (Silybum marianum), has anticancer and chemopreventive properties. Silibinin has been reported to inhibit the growth of various types of cancer cells. However, the mechanisms by which silibinin exerts an anticancer effect are poorly defined. The present study aimed to investigate whether silibinin-induced cell death might be attributed to autophagy...

Diabetes mellitus is a metabolic disorder that results in hyperglycemia due to decreased insulin production or inefficient insulin utilization. This disease has been reported in animals, particularly in aged dogs. However, the disorder is much more prevalent in humans. Millions of people across the globe currently have diabetes and incidence rates are predicted to increase dramatically as the p...

The study analyzed the biological (antimicrobial and antioxidant) activity of such medicinal plants grown in Kemerovo region as Leaf mustard ( Brassica juncea L. ), Stinging nettle Urtica dioica Maral root Rhaponticum carthamoides Thyme Thymus serpyllum Purple coneflower Echinacea purpúrea Chamomile Chamomilla recutita Milk thistle Sílybum mariánum Common marigold Caléndula officinális Tansy Ta...

milk thistle is used traditionally as a hepaprotective agent and supportive treatment of liver disorders. the most problems in milk thistle harvest are tall height, seed shedding and being spinous. in this trial, effects of 3 native populations (p1: isfahan violet flower, p 2: ahvaz white flower and p3: ahvaz violet flower) and 3 topping levels (t1:control, t2: topping in 7 leaves stage and t3:...