Abstarct: This study was carried out to compare the binding effects of rice and wheat starches with that of the official starch; maize starch BP. Granule properties such as angle of repose, moisture content, bulk and tapped densities, Hausner’s ratio, Carr’s index and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard metho...

An oral solid dosage form should ideally disperse into the primary particles from which it was prepared. Tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhance...

The present study was aimed towards the formulation and in vitro evaluation of orodispersible tablets by direct compression method using Risperidone as a model drug to enhance patient compliance. Orodispersible tablet of Risperidone was prepared by masking the bitter taste by cetyl alcohol using different ratios of drug with cetyl alcohol (2:1). Here crosspovidone and sodium starch glycolate in...

Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of zidovudine, an antiretroviral drug, were prepared using different superdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) and sodium starch glycollate by direct compression metho...

Retroviral integrase (IN) cleaves linear viral DNA specifically near the ends of the DNA (cleavage reaction) and subsequently couples the processed ends to phosphates in the target DNA (integration reaction). In vitro, IN catalyzes the disintegration reaction, which is the reverse of the integration reaction. Ideally, we would like to test the role of each amino acid in the IN protein. We mutag...

In the following study starch was isolated from the dried pulp of unripe pappaya fruit (Carica pappaya). The isolated starch was used as a binder in different concentrations in diclofenac sodium tablets. The tablets were formed by wet granulation method by using 2% w/v, 4% w/v, 6% w/v, 8% w/v and 10% w/v pappaya starch as binding agent. Formulated diclofenac sodium tablets were further evaluate...

Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Tizanidine Hydrochloride using Eudragit E 100 as a taste masking agent. Mass extrusion was the technique used for preparing taste masked granules. The tablet was prepared with three super disint...