This direct method for quantifying excessive urinary glycosaminoglycan excretion exploits the specific binding of 1,9-dimethylmethylene blue (DMB). The procedure obviates cumbersome and labor-intensive procedures for separating glycosaminoglycans from other constituents of urine. Pediatric pharmaceutical formulations (except heparin), in concentrations expected in urine, do not interfere with s...

The effect of natural (NE) and synthetic vitamin E supplementation (SE) on lamb meat packed under modified atmospheres (MAP) for 14 days was studied. Three hundred and sixty Rasa Aragonesa lambs were offered nine dietary treatments (0, NE125, NE250, NE500, NE1000, SE250, SE500, SE1000 and SE2000). Lambs had ad libitum access to the experimental compound feed and wheat straw, for 14 days (pre-sl...

Medulloblastomas (MBs) are primitive neuroectodermal tumors (PNET) of the cerebellum. They represent the most frequent malignant pediatric brain tumors, but their origin still remains unresolved and controversial. MB cells correspond to different stages of neural development and differentiation as illustrated by their expression of neuronal and glial markers. In the present study, we examined t...

The convergence of telecommunication and broadcasting is one of the representative innovative technologies in digital environment. It has recently been empathized as an alternative solution to overcome already saturated telecommunication and broadcasting markets. However, the growth of related service and market cannot reach prior expectation due to the lack of understanding on the real users. ...

Loss of cells in the human disc due to programmed cell death (apoptosis) is a major factor in the aging and degenerating human intervertebral disc. Our objective here was to determine if thymosin beta(4) (TB4), a small, multifunctional 5 kDa protein with diverse activities, might block apoptosis in human annulus cells cultured in monolayer or three-dimensional (3D) culture. Apoptosis was induce...

Very high-frequency (50–715 GHz) electron paramagnetic resonance (EPR) studies of the tetranuclear Co complex [Co(hmp)(dmb)Cl]4 (1), where dmb is 3,3-dimethyl-1-butanol and hmp is the monoanion of 2-hydroxy-methylpyridine, reveal the presence of significant zero-field-splitting (ZFS) within the ground state spin multiplet. Meanwhile, low-temperature hysteresis measurements of 1 (and related Co ...

Only select prokaryotes can biosynthesize vitamin B12 (i.e., cobalamins), but these organic co-enzymes are required by all microbial life and can be vanishingly scarce across extensive ocean biomes. Although global ocean genome data suggest cyanobacteria to be a major euphotic source of cobalamins, recent studies have highlighted that >95% of cyanobacteria can only produce a cobalamin analog, p...