Experimental and simulation-based investigations are carried out for the selective oxidation of green methanol to oxygenates dimethoxymethane (DMM) methyl formate (MF), including an initial catalyst screening, derivation a reaction kinetic model, feasibility study fixed-bed membrane reactor with oxygen distribution. The screening different supports loading vanadium revealed 6.6 wt.-% VOx/TiO2 o...

Abstract A dynamic nonlinear algebraic model with scale-similarity procedure (DNAM-SSD) is proposed for subgrid-scale (SGS) stress in large-eddy simulation of turbulence. The coefficients the DNAM-SSD are adaptively calculated through relation, which greatly simplifies conventional Germano-identity based (GID). a priori study shows that predicts SGS considerably better than velocity gradient (V...

Carbonylation gets a phase lift: The usual liquid-phase, high-pressure processes for carbonylating formaldehydes are avoided in a novel vapor-phase reaction. Using an acid zeolite (Faujasite) at near-atmospheric pressure dimethoxymethane (DMM; the dimethyl acetal of formaldehyde; see scheme) is carbonylated to produce methyl methoxyacetate (MMAc). This approach provides a new route to ethylene ...

The components of tumor cell surfaces that participate in the recognition and lysis of these cells by activated macrophages have not been identified. One plausible hypothesis is that these components are specific carbohydrate structures. As an initial test of this hypothesis, I have made use of the oligosaccharide processing inhibitors 1-deoxynojirimycin (dNM) and 1-deoxymannojirimycin (dMM). d...

OBJECTIVE Hypoxia-inducible factor 2α (HIF-2α), encoded by Epas1, causes osteoarthritic cartilage destruction by regulating the expression of matrix-degrading enzymes. We undertook this study to explore the role of nicotinamide phosphoribosyltransferase (NAMPT or visfatin) in HIF-2α-mediated osteoarthritic cartilage destruction. METHODS The expression of HIF-2α, NAMPT and matrix-degrading enz...

Overexpression of Smad ubiquitin regulatory factor 2 (Smurf2) in chondrocytes was reported to cause spontaneous osteoarthritis (OA) in mice. However, it is unclear whether Smurf2 is involved in bone and cartilage homeostasis and if it is required for OA pathogenesis. Here we characterized age-related changes in the bone and articular cartilage of Smurf2-deficient (MT) mice by microCT and histol...

Cu-exchanged Y zeolite was investigated in order to determine the location of the copper cations relative to the zeolite framework and to determine which Cu cations are active for the oxidative carbonylation of methanol to dimethyl carbonate (DMC). Cu-Y zeolite was prepared by vapor-phase exchange of H-Y with CuCl. The oxidation state, local coordination, and bond distances of Al and Cu were de...

Purpose: As we age or undergo trauma to the joint, gradual loss of cartilage matrix is accompanied with an increase in metalloproteinase 13 (MMP13) expression, causing osteoarthritis (OA). We and others have established that deacetylase sirtuin-1 (SIRT1) displays reduced activity during OA, evoking MMP13 expression damage. Here attempt decipher molecular mechanism by which regulated, assessing ...