The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating the effect of process variables on the response using Box-Behnken design. Effect of four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, was studied on two dependent responses, that is, z-average and % drug entrapment. Lzp-PLGA-NPs were successfull...

For the design and development of any novel formulation, assessment of compatibility of drug with excipients by different techniques such as thermal and isothermal stress testing are recommended. During pre-formulation studies common methods like UV-Spectrophotometric methods, FTIR are used for the study of compatibility. In the present investigation drug-excepient compatibility study of was co...

Purpose: To prepare and evaluate colon specific drug delivery system of diclofenac sodium for highly localized delivery to the colon. Methods: The colon specific drug delivery system was prepared as matrix-type microspheres using Ethyl Cellulose (EC), Cellulose Acetate Phthalate (CAP), and Eudragit L 100-55 by the Solvent Evaporation Method. Microspheres were evaluated for physical properties l...

Polymer–drug conjugates are an important polymeric therapeutic (PT) platform with drug molecules being attached by cleavable linkages to the pendant functional groups of linear, branched, brushed polymers that are typically synthesized prior to drug conjugation. The synthesis and conjugation processes developed to date, however, may not provide precise control over the composition and the struc...

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

abstractthe aim of the present study was to formulate poly (lactide-co-glycolide) (plga) nanoparticles loaded with 18-β-glycyrrhetinic acid (gla) with appropriate physicochemical properties and antimicrobial activity. gla loaded plga nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacterial activity of the developed nanopartic...

an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...

objective(s): researchers have intended to reformulate drugs so that they may be more safely used in human body. polymer science and nanotechnology have great roles in this field. the aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted ph-responsive polymer.  methods: fe3o4 na...

In the present study, an attempt was made to develop the pulsatile drug delivery of Lovastatin to the colon. Formaldehyde treated Capsule bodies were used for the preparation of pulsin caps. It was sealed with unhardened cap of the capsule. The microspheres were prepared by emulsion solvent evaporation technique. Optimized microsphere formulations were selected based on dissolution studies. Hyd...