Mesoporous silica nanoparticles with unique structure (SBA-15) were synthesized and modified by [3-(2-Aminoethylamino) propyl] trimethoxysilane (AEAPTMS). The synthesized nanoparticles were characterized by TGA, N‌2‌ adsorption, SEM, FTIR, CHN elemental analysis. The total weight loss for the modified SBA-15 is 15.2% and thermal analysis reveal...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

nowadays, environment-sensitive smart drug delivery systems have found diverse applications in pharmaceutical science and technology. these systems can respond to the environment stimuli such as temperature, pressure, ph, light, electrical and magnetical fields and etc. they can release the proper amount of drug in human body. among these systems, special attention and much research works have ...

In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microscopy , X-ray diffraction, and ultraviolet-visible. the Fourier transform infrared spectroscopy resu...

The goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. Nanoparticles are exhaled because of thier small size, Preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...

Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...