The growth-associated protein GAP-43 is a major protein kinase C substrate of growth cones and developing nerve terminals. In the growth cone, it accumulates near the plasma membrane, where it associates with the cortical cytoskeleton and membranes. The role of GAP-43 in neurite outgrowth is not yet clear, but recent findings suggest that it may be a crucial competence factor in this process. T...

For d 1 0 > and 4112 oriented tungsten tips deposited with liquid-gallium, electroll emission patterns and emissiol~ current characteristics were investigated by field emission micrc~scopy. When the tip ~ o l t a g c was applied for the first time after deposition of gallium, stable liquid-gallium cones were forn~ed on the remolded facets for thicknesses d 1.5 5nm and DC electron emission occur...

Collapsin response mediator proteins (CRMPs) have been implicated in signaling of axonal guidance, including semaphorins. We have previously identified a unique member of this gene family, CRMP-associated molecule CRAM (CRMP-5), which is phylogenetically divergent from the other four CRMPs. In this study, we have examined the distribution and function of CRAM in developing neurons. Immunohistoc...

Collapsin response mediator proteins (CRMPs) have been implicated in signaling of axonal guidance, including semaphorins. We have previously identified a unique member of this gene family, CRMP-associated molecule CRAM (CRMP-5), which is phylogenetically divergent from the other four CRMPs. In this study, we have examined the distribution and function of CRAM in developing neurons. Immunohistoc...

During development, axons of the mammalian corpus callosum must navigate across the midline to establish connections with corresponding targets in the contralateral cerebral cortex. To gain insight into how growth cones of callosal axons respond to putative guidance cues along this CNS pathway, we have used time-lapse video microscopy to observe dynamic behaviors of individual callosal growth c...

BACKGROUND Malignant gliomas represent one group of tumors that poorly respond to ionizing radiation (IR) alone or combined with chemotherapeutic agents because of the intrinsic or acquired resistance. In this study, TIP-1 was identified as one novel protein that confers resistance of glioma cells to IR. METHODOLOGY/PRINCIPAL FINDINGS Meta-analysis indicated that high TIP-1 expression levels ...

This paper presents the influence of non-linearity on the dynamic response of floating pile foundation subject to vertical vibration. A detailed theoretical investigation of stiffness and damping parameters is made for floating piles with different shear modulus reduction ratio of the weak zone soil. The accuracy of the non-linear analysis for predicting the dynamic response depends upon the ch...