OBJECTIVE To determine the relationship of interpregnancy interval with maternal and offspring outcomes. DESIGN Retrospective study with data from the Perinatal Information System database of the Latin American Centre for Perinatology and Human Development, Uruguay. SETTING Latin America, 1990-2009. POPULATION A cohort of 894 476 women delivering singleton infants. METHODS During 1990-2...

BACKGROUND Sub-Saharan Africa has the highest maternal mortality ratio at 500 deaths per 100,000 live births. In Mozambique maternal mortality is estimated at 249-480 per 100,000 live births and eclampsia is the third leading cause of death. The objective of this study was to describe the community understanding of pre-eclampsia and eclampsia, as a crucial step to improve maternal and perinatal...

Background: Pre-eclampsia is a major cause of maternal and perinatal death. Parameters derived from the Doppler waveform in different vascular beds have been studied as possible predictors of pre-eclampsia. Objectives: To assess whether second –trimester changes in transcranial Doppler parameters of normotensive pregnant woman are associated with the subsequent development of pre-eclampsia. Sea...

We investigated the correlation between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene methylation and pre-eclampsia, and its clinical significance, by comparing methylation in the MTHFR gene promoter of the placenta and peripheral venous blood in pre-eclampsia and normal gravidas. We enrolled 259 gravidas from the People's Liberation Army 202nd Hospital, China, between January 2011 and ...

OBJECTIVE To estimate the contributions of biological aging, historical trends, and birth cohort effects on trends in pre-eclampsia in the United States. DESIGN Population based retrospective study. SETTING National hospital discharge survey datasets, 1980-2010, United States. PARTICIPANTS 120 million women admitted to hospital for delivery. MAIN OUTCOME MEASURES Temporal changes in rat...

BACKGROUND Pre-eclampsia is a potentially serious condition that still accounts for significant morbidity and mortality for the affected mother and neonate. Although the pathogenesis is not fully understood, it is now widely accepted that vascular endothelial dysfunction is the most important and principal event in the pathophysiology of the disease. The aims of our study were to compare serum ...

OBJECTIVES To determine whether pre-eclampsia, hypothesised to be an inflammatory condition, is associated with fever in term labour, and confirm and examine the reported association of pre-eclampsia at term with neonatal encephalopathy. DESIGN Prospective cohort study. SETTING A Dublin teaching hospital. PARTICIPANTS 6163 women in labour with singleton pregnancies at term at low risk for...

Pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-l-beta (IL-lβ) and tumor necrosis factor alpha (TNF-α) genes are associated with pr-eeclampsia in several studies in different popul...