Purpose of the study . Evaluation antioxidant status and DNA damage in tissues subcutaneous xenografts non-small cell lung cancer peritumoral created using A549 H1299 cultures. Materials methods The included 35 intact male Balb/c Nude immunodeficient mice. Cell lines were used as transplantable tumor biomaterial. A CDX model was accordance with protocol for supratentorial injections (Ozawa T., ...

Two unusual variants of cholinesterase (acylcholineacylhydrolase, 3.1.1.8) have been recognized by the use of differential inhibitors (Kalow and Genest, 1957; Harris and Whittaker, 1961). A third variant, the silent gene, determines an absent or greatly reduced serum cholinesterase level in the affected homozygote (Liddell, Lehmann, and Silk, 1962). These variants are alleles, and the affected ...

OBJECTIVE In chronic hemodialyzed (CH) patients the balance between production of reactive oxygen species and antioxidant defense system is disturbed and shifted towards oxidative conditions. The properties of albumin in CH patients were studied before hemodialysis (HD) and post-HD. METHODS Two oxidants were applied, organic t-butyl hydroperoxide (t-BOOH) and inorganic hydroperoxide (H2O2), f...

The effect of different L-phenylalanine (Phe) concentrations (0.1-12.1 mM), on acetylcholinesterase (AChE) and Na+,K(+)-ATPase activities of brain homogenate and pure enzymes, was investigated at 37 degrees C. AChE and Na+,K(+)-ATPase activities were determined according to Ellman G. L., Courtney D., Andres V. and Featherstone R. M. (1961), Biochem. Pharmacol. 7, 88-95 and Bowler K. and Tirri R...

In 1943 Henrik Sj6gren first described the syndrome which bears his name. It is generally recognized that the diagnosis can be made when any two of the following three features are present: xerostomia with or without salivary gland enlargement, keratoconjunctivitis sicca, and connective tissue disease, usually rheumatoid arthritis (Bunim, 1961; Bloch and Bunim, 1963). The xerostomia and keratoc...

Glycocholate and taurocholate have been shown (Coleman & Holdsworth, 1976; Billington & Coleman, 1978) to release significant amounts of membrane proteins and phospholipid from erythrocytes before the occurrence of significant cell lysis. Our particular interest was to study in detail the release of acetylcholinesterase from human erythrocytes. Heparinized human blood was centrifuged at 2500g f...

The synthesis and characterization of diastereomers of cocaine benzoyl thioester is described. Allococaine benzoyl thioester and allopseudococaine benzoyl thioester were synthesized by the conjugate addition of p-methoxytolyl thiol to ecgonine methyl ester followed by debenzylation and benzoylation. The absolute structure of the hydrochloride salt of the major ecgonine p-methoxytolyl sulfide fo...