Renal Sympathetic Hyperactivity in Hypertension: True or False? To the Editor: Increased renal norepinephrine spillover, observed by using isotope-dilution method, is thought to indicate renal sympathetic hyperactivity and to play a crucial role in hypertension. However, SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension), the first randomized shamcontrolled trial, f...

Renal Sympathetic Hyperactivity in Hypertension: True or False? To the Editor: Increased renal norepinephrine spillover, observed by using isotope-dilution method, is thought to indicate renal sympathetic hyperactivity and to play a crucial role in hypertension. However, SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension), the first randomized shamcontrolled trial, f...

Renal Sympathetic Hyperactivity in Hypertension: True or False? To the Editor: Increased renal norepinephrine spillover, observed by using isotope-dilution method, is thought to indicate renal sympathetic hyperactivity and to play a crucial role in hypertension. However, SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension), the first randomized shamcontrolled trial, f...

Taurine is an important regulator of cellular ion transport and osmotic balance, aspects that are pivotal to renal function. The kidney not only regulates body taurine status, but emerging information also suggests that body taurine status is of consequence for renal function. While reduction in endogenous taurine stores can attenuate renal excretory function, exogenous taurine supplementation ...

any, uric acid. The biological literature contains abundant evidence that most excretory nitrogen of birds is in the form of uric acid or its salts (2). Most of Folk's data on the white part (the urine) of bird droppings are not inconsistent with this generalization. (i) Folk finds that bird droppings exhibit only part of the x-ray analysis pattern typical of uric acid or two of its salts. We w...

A canonical Ras-ERK signaling pathway specifies the fate of the excretory duct cell during Caenorhabditis elegans embryogenesis. The paralogs ksr-1 and ksr-2 encode scaffolding proteins that facilitate signaling through this pathway and that act redundantly to promote the excretory duct fate. In a genomewide RNAi screen for genes that, like ksr-2, are required in combination with ksr-1 for the ...

Symbiosis is an important driving force in metazoan evolution and the study of ancient lineages can provide an insight into the influence of symbiotic associations on morphological and physiological adaptations. In the 'living fossil' Nautilus, bacterial associations are found in the highly specialized pericardial appendage. This organ is responsible for most of the excretory processes (ultrafi...

Glutathione peroxidases (GPx) and glutathione S-transferases (GST) are essential enzymes of the cellular defense system. The aim of this work was the identification of GPx transcript in a freshwater bivalve, Unio tumidus, and the effects of Aroclor 1254 on GPx and pi-class GST (pi-GST) expression pattern. The GPx full-length coding sequence was obtained by reverse transcription PCR using degene...

Liver tissue constructs with excretory function are crucial to developing realistic hepatocyte models for engineering effective bioartificial liver-assisted devices and for modeling the in vivo tissue. Current hepatocyte in vitro models suffer from limited or inefficient hepatocyte repolarization, which results in poor removal of xenobiotics and other waste products from the cells. We hypothesi...